Display options
Cite
Rajendran BK, Xavier Suresh M, Bhaskaran SP, et al. Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, . Comput Struct Biotechnol J. 2018;16:450-461doi: 10.1016/j.csbj.2018.10.005.
Rajendran, B. K., Xavier Suresh, M., Bhaskaran, S. P., Harshitha, Y., Gaur, U., & Kwok, H. F. (2018). Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, . Computational and structural biotechnology journal, 16450-461. https://doi.org/10.1016/j.csbj.2018.10.005
Rajendran, Barani Kumar, et al. "Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, ." Computational and structural biotechnology journal vol. 16 (2018): 450-461. doi: https://doi.org/10.1016/j.csbj.2018.10.005
Rajendran BK, Xavier Suresh M, Bhaskaran SP, Harshitha Y, Gaur U, Kwok HF. Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, . Comput Struct Biotechnol J. 2018 Oct 31;16:450-461. doi: 10.1016/j.csbj.2018.10.005. eCollection 2018. PMID: 30455855; PMCID: PMC6231056.
Copy Download .nbib Format: NLM
Share it on

Comput Struct Biotechnol J. 2018 Oct 31;16:450-461. doi: 10.1016/j.csbj.2018.10.005. eCollection 2018.

Pharmacoinformatic Approach to Explore the Antidote Potential of Phytochemicals on Bungarotoxin from Indian Krait, .

Computational and structural biotechnology journal

Barani Kumar Rajendran, M Xavier Suresh, Shanmuga Priya Bhaskaran, Yarradoddi Harshitha, Uma Gaur, Hang Fai Kwok

Affiliations

  1. Institute of Translational Medicine, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau.
  2. Department of Physics, Sathyabama Institute of Science and Technology, Deemed to be University, Chennai 600119, India.

PMID: 30455855 PMCID: PMC6231056 DOI: 10.1016/j.csbj.2018.10.005

Abstract

Venomous reptiles especially serpents are well known for their adverse effects after accidental conflicts with humans. Upon biting humans these serpents transmit arrays of detrimental toxins with diverse physiological activities that may either lead to minor symptoms such as dermatitis and allergic response or highly severe symptoms such as blood coagulation, disseminated intravascular coagulation, tissue injury, and hemorrhage. Other complications like respiratory arrest and necrosis may also occur. Bungarotoxins are a group of closely related neurotoxic proteins derived from the venom of kraits (

Keywords: Bungarotoxin; Drug design; Molecular docking; Molecular dynamics; Pharmacokinetic profiling; Toxins

References

  1. Toxicon. 2003 Mar;41(4):397-407 - PubMed
  2. Neuropharmacology. 2015 Jun;93:28-40 - PubMed
  3. Toxicon. 2005 Mar 1;45(3):293-301 - PubMed
  4. Sci Rep. 2017 Mar 03;7:42717 - PubMed
  5. Science. 2001 Oct 5;294(5540):93-6 - PubMed
  6. J Pharmacol Sci. 2004 Jan;94(1):1-17 - PubMed
  7. Nucleic Acids Res. 2000 Jan 1;28(1):235-42 - PubMed
  8. PLoS Negl Trop Dis. 2013 Oct 10;7(10):e2302 - PubMed
  9. Curr Med Chem. 2005;12(22):2625-41 - PubMed
  10. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6629-34 - PubMed
  11. Biochemistry. 1992 Mar 24;31(11):2962-70 - PubMed
  12. Nat Neurosci. 2007 Aug;10(8):953-62 - PubMed
  13. Nucleic Acids Res. 2005 Apr 01;33(6):1874-91 - PubMed
  14. PLoS Negl Trop Dis. 2016 Feb 01;10(2):e0004368 - PubMed
  15. Biophys J. 2003 Aug;85(2):943-53 - PubMed
  16. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D154-9 - PubMed
  17. J Biomol Struct Dyn. 2017 Jun;35(8):1654-1671 - PubMed
  18. J Cell Mol Med. 2018 Sep;22(9):4460-4473 - PubMed
  19. J Biomed Sci. 1999 Nov-Dec;6(6):368-75 - PubMed
  20. Chimia (Aarau). 2012;66(5):320-3 - PubMed
  21. Natl Med J India. 1998 Nov-Dec;11(6):264-5 - PubMed
  22. PLoS One. 2011;6(6):e20695 - PubMed
  23. J Proteomics. 2017 Jul 5;164:1-18 - PubMed
  24. Ther Drug Monit. 2000 Feb;22(1):65-8 - PubMed
  25. Pharmacogn Mag. 2015 May;11(Suppl 1):S19-28 - PubMed
  26. Br J Clin Pharmacol. 2016 Mar;81(3):446-52 - PubMed
  27. Proteins. 2001 Jan 1;42(1):6-16 - PubMed
  28. World J Biol Chem. 2015 May 26;6(2):28-33 - PubMed
  29. Toxicon. 2010 Nov;56(6):855-67 - PubMed
  30. Nucleic Acids Res. 2016 Jan 4;44(D1):D1202-13 - PubMed
  31. J Ethnopharmacol. 2008 Jan 17;115(2):302-12 - PubMed
  32. Toxicon. 2012 Mar 15;59(4):456-63 - PubMed
  33. Postgrad Med J. 2002 May;78(919):276-80 - PubMed
  34. Chem Biol. 2001 Feb;8(2):147-55 - PubMed
  35. Phytochemistry. 2000 Nov;55(6):627-42 - PubMed
  36. Int J Quantum Chem Quantum Biol Symp. 1986;13:167-74 - PubMed
  37. Toxins (Basel). 2016 Oct 18;8(10): - PubMed
  38. Cell Mol Life Sci. 2006 Dec;63(24):3030-41 - PubMed
  39. Oncotarget. 2017 Oct 11;8(59):100908-100930 - PubMed

Publication Types