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Toshiyuki Matsumi C, José da Silva W, Kurt Schneider F, et al. Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation. Micromachines (Basel). 2018;9(8)doi: 10.3390/mi9080387.
Toshiyuki Matsumi, C., José da Silva, W., Kurt Schneider, F., Miguel Maia, J., E M Morales, R., & Duarte Araújo Filho, W. (2018). Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation. Micromachines, 9(8), . https://doi.org/10.3390/mi9080387
Toshiyuki Matsumi, Carlos, et al. "Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation." Micromachines vol. 9,8 (2018). doi: https://doi.org/10.3390/mi9080387
Toshiyuki Matsumi C, José da Silva W, Kurt Schneider F, Miguel Maia J, E M Morales R, Duarte Araújo Filho W. Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation. Micromachines (Basel). 2018 Aug 04;9(8). doi: 10.3390/mi9080387. PMID: 30424320; PMCID: PMC6187383.
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Micromachines (Basel). 2018 Aug 04;9(8). doi: 10.3390/mi9080387.

Micropipette-Based Microfluidic Device for Monodisperse Microbubbles Generation.

Micromachines

Carlos Toshiyuki Matsumi, Wilson José da Silva, Fábio Kurt Schneider, Joaquim Miguel Maia, Rigoberto E M Morales, Walter Duarte Araújo Filho

Affiliations

  1. Department of Electronics, Federal Institute of Education, Science and Technology of Santa Catarina (IFSC), Joinville, SC 89220-618, Brazil. [email protected].
  2. Graduate Program in Electrical and Computer Engineering (CPGEI) and Electronics Engineering Department (DAELN), Federal University of Technology Paraná (UTFPR), Curitiba, PR 80230-901, Brazil. [email protected].
  3. Graduate Program in Electrical and Computer Engineering (CPGEI) and Electronics Engineering Department (DAELN), Federal University of Technology Paraná (UTFPR), Curitiba, PR 80230-901, Brazil. [email protected].
  4. Graduate Program in Electrical and Computer Engineering (CPGEI) and Electronics Engineering Department (DAELN), Federal University of Technology Paraná (UTFPR), Curitiba, PR 80230-901, Brazil. [email protected].
  5. Graduate Program in Mechanical and Material Engineering (PPGEM) and Department of Mechanics (DAMEC), Federal University of Technology Paraná (UTFPR), Curitiba, PR 80230-901, Brazil. [email protected].
  6. Department of Exact and Earth Sciences (DCET), University of the State of Bahia (UNEB), Salvador, BA 41150-000, Brazil. [email protected].

PMID: 30424320 PMCID: PMC6187383 DOI: 10.3390/mi9080387

Abstract

Microbubbles have various applications including their use as carrier agents for localized delivery of genes and drugs and in medical diagnostic imagery. Various techniques are used for the production of monodisperse microbubbles including the Gyratory, the coaxial electro-hydrodynamic atomization (CEHDA), the sonication methods, and the use of microfluidic devices. Some of these techniques require safety procedures during the application of intense electric fields (e.g., CEHDA) or soft lithography equipment for the production of microfluidic devices. This study presents a hybrid manufacturing process using micropipettes and 3D printing for the construction of a T-Junction microfluidic device resulting in simple and low cost generation of monodisperse microbubbles. In this work, microbubbles with an average size of 16.6 to 57.7 μm and a polydispersity index (PDI) between 0.47% and 1.06% were generated. When the device is used at higher bubble production rate, the average diameter was 42.8 μm with increased PDI of 3.13%. In addition, a second-order polynomial characteristic curve useful to estimate micropipette internal diameter necessary to generate a desired microbubble size is presented and a linear relationship between the ratio of gaseous and liquid phases flows and the ratio of microbubble and micropipette diameters (i.e., Q

Keywords: 3D printing microfluidic devices; cross-flow; microbubbles; micropipettes

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