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Koh EM, Lee EK, Song CH, et al. Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation. Toxicol Res. 2018;34(4):333-341doi: 10.5487/TR.2018.34.4.333.
Koh, E. M., Lee, E. K., Song, C. H., Song, J., Chung, H. Y., Chae, C. H., & Jung, K. J. (2018). Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation. Toxicological research, 34(4), 333-341. https://doi.org/10.5487/TR.2018.34.4.333
Koh, Eun Mi, et al. "Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation." Toxicological research vol. 34,4 (2018): 333-341. doi: https://doi.org/10.5487/TR.2018.34.4.333
Koh EM, Lee EK, Song CH, Song J, Chung HY, Chae CH, Jung KJ. Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation. Toxicol Res. 2018 Oct;34(4):333-341. doi: 10.5487/TR.2018.34.4.333. Epub 2018 Oct 15. PMID: 30370008; PMCID: PMC6195880.
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Toxicol Res. 2018 Oct;34(4):333-341. doi: 10.5487/TR.2018.34.4.333. Epub 2018 Oct 15.

Ferulate, an Active Component of Wheat Germ, Ameliorates Oxidative Stress-Induced PTK/PTP Imbalance and PP2A Inactivation.

Toxicological research

Eun Mi Koh, Eun Kyeong Lee, Chi Hun Song, Jeongah Song, Hae Young Chung, Chang Hoon Chae, Kyung Jin Jung

Affiliations

  1. Bioanalytical and Immunoanalytical Research Group, Korea Institute of Toxicology, Daejeon, Korea.
  2. Animal Model Research Center, Korea Institute of Toxicology, Jeonbuk, Korea.
  3. Molecular Inflammation Research Center for Aging Intervention (MRCA), College of Pharmacy, Pusan National University, Busan, Korea.
  4. Celldi, 2-212 Jeonbuk TechnoPark, Wanju, Korea.
  5. Department of Human and Environmental Toxicology, Korea University of Science and Technology (UST), Daejeon, Korea.

PMID: 30370008 PMCID: PMC6195880 DOI: 10.5487/TR.2018.34.4.333

Abstract

Ferulate is a phenolic compound abundant in wheat germ and bran and has been investigated for its beneficial activities. The aim of the present study is to evaluate the efficacy of ferulate against the oxidative stress-induced imbalance of protein tyrosine kinases (PTKs), protein tyrosine phosphatases (PTPs), and serine/threonine protein phosphatase 2A (PP2A), in connection with our previous finding that oxidative stress-induced imbalance of PTKs and PTPs is linked with proinflammatory nuclear factor-kappa B (NF-κB) activation. To test the effects of ferulate on this process, we utilized two oxidative stress-induced inflammatory models. First, YPEN-1 cells were pretreated with ferulate for 1 hr prior to the administration of 2,2'-Azobis(2-methylpropionamidine) dihydrochloride (AAPH). Second, 20-month-old Sprague-Dawley rats were fed ferulate for 10 days. After ferulate treatment, the activities of PTKs, PTPs, and PP2A were measured because these proteins either directly or indirectly promote NF-κB activation. Our results revealed that in YPEN-1 cells, ferulate effectively suppressed AAPH-induced increases in reactive oxygen species (ROS) and NF-κB activity, as well as AAPH-induced PTK activation. Furthermore, ferulate also inhibited AAPH-induced PTP and PP2A inactivation. In the aged kidney model, ferulate suppressed aging-induced activation of PTKs and ameliorated aging-induced inactivation of PTPs and PP2A. Thus, herein we demonstrated that ferulate could modulate PTK/PTP balance against oxidative stress-induced inactivation of PTPs and PP2A, which is closely linked with NF-κB activation. Based on these results, the ability of ferulate to modulate oxidative stress-related inflammatory processes is established, which suggests that this compound could act as a novel therapeutic agent.

Keywords: Ferulate; Oxidative stress; PP2A; PTK; PTP; Wheat germ

Conflict of interest statement

CONFLICT OF INTEREST The authors declare no potential conflicts of interests.

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