Display options
Cite
Limper M, Scirè CA, Talarico R, et al. Antiphospholipid syndrome: state of the art on clinical practice guidelines. RMD Open. 2018;4:e000785doi: 10.1136/rmdopen-2018-000785.
Limper, M., Scirè, C. A., Talarico, R., Amoura, Z., Avcin, T., Basile, M., Burmester, G., Carli, L., Cervera, R., Costedoat-Chalumeau, N., Doria, A., Dörner, T., Fonseca, J. E., Galetti, I., Hachulla, E., Launay, D., Lourenco, F., Macieira, C., Meroni, P., Montecucco, C. M., Moraes-Fontes, M. F., Mouthon, L., Nalli, C., Ramoni, V., Tektonidou, M., van Laar, J. M., Bombardieri, S., Schneider, M., Smith, V., Vieira, A., Cutolo, M., Mosca, M., & Tincani, A. (2018). Antiphospholipid syndrome: state of the art on clinical practice guidelines. RMD open, 4e000785. https://doi.org/10.1136/rmdopen-2018-000785
Limper, Marteen, et al. "Antiphospholipid syndrome: state of the art on clinical practice guidelines." RMD open vol. 4 (2018): e000785. doi: https://doi.org/10.1136/rmdopen-2018-000785
Limper M, Scirè CA, Talarico R, Amoura Z, Avcin T, Basile M, Burmester G, Carli L, Cervera R, Costedoat-Chalumeau N, Doria A, Dörner T, Fonseca JE, Galetti I, Hachulla E, Launay D, Lourenco F, Macieira C, Meroni P, Montecucco CM, Moraes-Fontes MF, Mouthon L, Nalli C, Ramoni V, Tektonidou M, van Laar JM, Bombardieri S, Schneider M, Smith V, Vieira A, Cutolo M, Mosca M, Tincani A. Antiphospholipid syndrome: state of the art on clinical practice guidelines. RMD Open. 2018 Oct 18;4:e000785. doi: 10.1136/rmdopen-2018-000785. eCollection 2018. PMID: 30402272; PMCID: PMC6203101.
Copy Download .nbib Format: NLM
Share it on

RMD Open. 2018 Oct 18;4:e000785. doi: 10.1136/rmdopen-2018-000785. eCollection 2018.

Antiphospholipid syndrome: state of the art on clinical practice guidelines.

RMD open

Marteen Limper, Carlo Alberto Scirè, Rosaria Talarico, Zahir Amoura, Tadej Avcin, Martina Basile, Gerd Burmester, Linda Carli, Ricard Cervera, Nathalie Costedoat-Chalumeau, Andrea Doria, Thomas Dörner, João Eurico Fonseca, Ilaria Galetti, Eric Hachulla, David Launay, Filipa Lourenco, Carla Macieira, Pierluigi Meroni, Carlo Maurizio Montecucco, Maria Francisca Moraes-Fontes, Luc Mouthon, Cecilia Nalli, Veronique Ramoni, Maria Tektonidou, Jacob M van Laar, Stefano Bombardieri, Matthias Schneider, Vanessa Smith, Ana Vieira, Maurizio Cutolo, Marta Mosca, Angela Tincani

Affiliations

  1. Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
  2. Section of Rheumatology, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
  3. Rheumatology Unit, AOU Pisana, Pisa, Italy.
  4. Department of Internal Medicine, Hospital Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Paris, France.
  5. Department of Allergology, Rheumatology and Clinical Immunology, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia.
  6. Lissone, Lissone, Italy.
  7. Department of Rheumatology and Clinical Immunology, Charité University Hospital Berlin, Berlin, Germany.
  8. Department of Autoimmune Diseases, Hospital Clínic de Barcelona, Barcelona, Spain.
  9. Service de Médecine Interne, Hôpital Cochin, Centre de Référence Maladies systémiques Autoimmunes Rares d'Ile de France, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Descartes, Paris, France.
  10. Rheumatology Unit, Department of Medicine, AO Padova and University of Padua, Padua, Italy.
  11. Rheumatology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisbon Academic Medical Centre, Lisbon, Portugal.
  12. Federation of European Scleroderma Associations (FESCA), Milan, Italy.
  13. Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Systémiques et Auto-Immunes Rares du Nord-Ouest (CERAINO), LIRIC, INSERM, Univ. Lille, CHU Lille, Lille, France.
  14. Auto-immune Disease Unit, Hospital de Curry Cabral, Centro Hospitalar de Lisboa Central, EPE, Lisbon, Portugal.
  15. Division of Rheumatology, ASST.G Pini, Department of Clinical Sciences and Community Health, University of Milan and Istituto Auxologico Italiano, Milan, Italy.
  16. Division of Rheumatology, University and IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
  17. Rheumatology and Clinical Immunology Unit, Civil Hospital, Brescia, Italy.
  18. Joint Rheumatology Academic Program, First Department of Propaedeutic Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
  19. University of Pisa, Pisa, Italy.
  20. Department of Rheumatology, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
  21. Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
  22. Department of Internal Medicine, Ghent University, Ghent, Belgium.
  23. Liga Portuguesa Contra as Doenças Reumáticas, Núcleo Síndrome de Sjögren, Lisbon, Portugal.
  24. Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, IRCCS Polyclinic Hospital San Martino, University of Genoa, Genoa, Italy.
  25. Rheumatology Unit, University of Pisa, Pisa, Italy.

PMID: 30402272 PMCID: PMC6203101 DOI: 10.1136/rmdopen-2018-000785

Abstract

Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers.

Keywords: ERN ReCONNET; European reference networks; antiphospholipid syndrome; clinical practice guidelines; unmet needs

Conflict of interest statement

Competing interests: None declared.

References

  1. Autoimmun Rev. 2015 May;14(5):401-14 - PubMed
  2. Autoimmun Rev. 2015 Jun;14(6):498-502 - PubMed
  3. Clin Exp Rheumatol. 2013 Nov-Dec;31(6):877-82 - PubMed
  4. Br J Haematol. 2012 Apr;157(1):47-58 - PubMed
  5. Immunol Res. 2017 Feb;65(1):17-24 - PubMed
  6. J Autoimmun. 2018 Aug;92:1-11 - PubMed
  7. J Clin Invest. 2016 Aug 1;126(8):2933-40 - PubMed
  8. J Reprod Immunol. 2016 Jun;115:14-9 - PubMed
  9. Medicine (Baltimore). 2014 Nov;93(26):e143 - PubMed
  10. Arthritis Rheum. 2012 Aug;64(8):2719-23 - PubMed
  11. Ann Rheum Dis. 2008 Feb;67(2):195-205 - PubMed
  12. Clin Chim Acta. 2015 Jun 15;446:201-5 - PubMed
  13. Semin Arthritis Rheum. 2017 Feb;46(4):e21-e23 - PubMed
  14. Blood. 2011 Jun 23;117(25):6948-51 - PubMed
  15. J Rheumatol. 2017 Nov;44(11):1597-1602 - PubMed
  16. Autoimmun Rev. 2014 Mar;13(3):281-91 - PubMed
  17. Autoimmun Rev. 2014 Sep;13(9):917-30 - PubMed
  18. Lupus. 2003;12(7):504-7 - PubMed
  19. Chest. 2012 Feb;141(2 Suppl):e691S-e736S - PubMed
  20. J Thromb Haemost. 2009 Oct;7(10):1737-40 - PubMed
  21. Lupus. 2018 Mar;27(3):399-406 - PubMed
  22. Blood. 2018 Sep 27;132(13):1365-1371 - PubMed
  23. Thromb Res. 2005;115(1-2):3-8 - PubMed
  24. Ann Rheum Dis. 2017 Mar;76(3):476-485 - PubMed
  25. Lupus. 2003;12(7):530-4 - PubMed
  26. Autoimmun Rev. 2014 Aug;13(8):795-813 - PubMed
  27. Autoimmun Rev. 2014 Jun;13(6):685-96 - PubMed
  28. Lupus. 2011 Feb;20(2):206-18 - PubMed
  29. Eur J Obstet Gynecol Reprod Biol. 2016 Jun;201:18-26 - PubMed
  30. Ann Rheum Dis. 2017 Oct;76(10):1637-1641 - PubMed
  31. J Thromb Haemost. 2015 May;13(5):782-7 - PubMed
  32. Arthritis Rheum. 2007 Jul;56(7):2382-91 - PubMed
  33. J Thromb Haemost. 2018 Jun 7;:null - PubMed
  34. Nat Rev Rheumatol. 2015 Oct;11(10):586-96 - PubMed
  35. Ann Rheum Dis. 2010 Dec;69(12):2074-82 - PubMed
  36. Ann Rheum Dis. 2016 Dec;75(12):e81 - PubMed
  37. Lupus. 2003;12(7):499-503 - PubMed
  38. Arthritis Rheum. 2013 Feb;65(2):464-71 - PubMed
  39. Arthritis Rheum. 2012 Jan;64(1):1-10 - PubMed
  40. J Rheumatol. 2017 Aug;44(8):1165-1172 - PubMed

Publication Types