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Van Herck M, Spruit MA, Burtin C, et al. Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease. J Clin Med. 2018;7(12)doi: 10.3390/jcm7120471.
Van Herck, M., Spruit, M. A., Burtin, C., Djamin, R., Antons, J., Goërtz, Y. M. J., Ebadi, Z., Janssen, D. J. A., Vercoulen, J. H., Peters, J. B., Thong, M. S. Y., Otker, J., Coors, A., Sprangers, M. A. G., Muris, J. W. M., Wouters, E. F. M., & van 't Hul, A. J. (2018). Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease. Journal of clinical medicine, 7(12), . https://doi.org/10.3390/jcm7120471
Van Herck, Maarten, et al. "Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease." Journal of clinical medicine vol. 7,12 (2018). doi: https://doi.org/10.3390/jcm7120471
Van Herck M, Spruit MA, Burtin C, Djamin R, Antons J, Goërtz YMJ, Ebadi Z, Janssen DJA, Vercoulen JH, Peters JB, Thong MSY, Otker J, Coors A, Sprangers MAG, Muris JWM, Wouters EFM, van 't Hul AJ. Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease. J Clin Med. 2018 Nov 23;7(12). doi: 10.3390/jcm7120471. PMID: 30477110; PMCID: PMC6306949.
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J Clin Med. 2018 Nov 23;7(12). doi: 10.3390/jcm7120471.

Fatigue is Highly Prevalent in Patients with Asthma and Contributes to the Burden of Disease.

Journal of clinical medicine

Maarten Van Herck, Martijn A Spruit, Chris Burtin, Remco Djamin, Jeanine Antons, Yvonne M J Goërtz, Zjala Ebadi, Daisy J A Janssen, Jan H Vercoulen, Jeannette B Peters, Melissa S Y Thong, Jacqueline Otker, Arnold Coors, Mirjam A G Sprangers, Jean W M Muris, Emiel F M Wouters, Alex J van 't Hul

Affiliations

  1. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. [email protected].
  2. Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. [email protected].
  3. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. [email protected].
  4. Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. [email protected].
  5. Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), 6229 HX Maastricht, The Netherlands. [email protected].
  6. NUTRIM School of Nutrition and Translational Research in Metabolism, 6229 ER Maastricht, The Netherlands. [email protected].
  7. REVAL Rehabilitation Research Center, BIOMED Biomedical Research Institute, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium. [email protected].
  8. Department of Respiratory Medicine, Amphia Hospital, 4818 CK Breda, The Netherlands. [email protected].
  9. Department of Pulmonary Medicine, Radboud University Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands. [email protected].
  10. Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. [email protected].
  11. Department of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. [email protected].
  12. Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. [email protected].
  13. Centre of expertise for palliative care, MUMC+, 6229 HX Maastricht, The Netherlands. [email protected].
  14. Department of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. [email protected].
  15. Department of Medical Psychology, Radboudumc, 6525 GA Nijmegen, The Netherlands. [email protected].
  16. Department of Medical Psychology, Amsterdam University Medical Centers, location AMC, 1105 AZ Amsterdam, The Netherlands. [email protected].
  17. Member of Lung Foundation Netherlands, 3818 LE Amersfoort, The Netherlands. [email protected].
  18. Member of Patient Advisory Board, Radboudumc, 6525 GA Nijmegen, The Netherlands. [email protected].
  19. Department of Medical Psychology, Amsterdam University Medical Centers, location AMC, 1105 AZ Amsterdam, The Netherlands. [email protected].
  20. Department of General Practice, MUMC+, 6229 HX Maastricht, The Netherlands. [email protected].
  21. Department of Research and Education, CIRO, Centre of Expertise for Chronic Organ Failure, 6085 NM Horn, The Netherlands. [email protected].
  22. Department of Respiratory Medicine, Maastricht University Medical Center (MUMC+), 6229 HX Maastricht, The Netherlands. [email protected].
  23. Department of Pulmonary Medicine, Radboud University Medical Center (Radboudumc), 6525 GA Nijmegen, The Netherlands. [email protected].

PMID: 30477110 PMCID: PMC6306949 DOI: 10.3390/jcm7120471

Abstract

The 2018 update of the Global Strategy for Asthma Management and Prevention does not mention fatigue-related symptoms. Nevertheless, patients with asthma frequently report tiredness, lack of energy, and daytime sleepiness. Quantitative research regarding the prevalence of fatigue in asthmatic patients is lacking. This retrospective cross-sectional study of outpatients with asthma upon referral to a chest physician assessed fatigue (Checklist Individual Strength-Fatigue (CIS-Fatigue)), lung function (spirometry), asthma control (Asthma Control Questionnaire (ACQ)), dyspnea (Medical Research Council (MRC) scale), exercise capacity (six-minute walk test (6MWT)), and asthma-related Quality-of-Life (QoL), Asthma Quality of Life Questionnaire (AQLQ) during a comprehensive health-status assessment. In total, 733 asthmatic patients were eligible and analyzed (47.4 ± 16.3 years, 41.1% male). Severe fatigue (CIS-Fatigue ≥ 36 points) was detected in 62.6% of patients. Fatigue was not related to airflow limitation (FEV1,

Keywords: asthma; fatigue; quality of life

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