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Wang M, Ma R, Wu D, et al. Value of lung perfusion scintigraphy in patients with idiopathic pulmonary arterial hypertension: a patchy pattern to consider. Pulm Circ. 2018;9(1):2045894018816968doi: 10.1177/2045894018816968.
Wang, M., Ma, R., Wu, D., Xiong, C., He, J., Wang, L., Sun, X., & Fang, W. (2019). Value of lung perfusion scintigraphy in patients with idiopathic pulmonary arterial hypertension: a patchy pattern to consider. Pulmonary circulation, 9(1), 2045894018816968. https://doi.org/10.1177/2045894018816968
Wang, Meng, et al. "Value of lung perfusion scintigraphy in patients with idiopathic pulmonary arterial hypertension: a patchy pattern to consider." Pulmonary circulation vol. 9,1 (2019): 2045894018816968. doi: https://doi.org/10.1177/2045894018816968
Wang M, Ma R, Wu D, Xiong C, He J, Wang L, Sun X, Fang W. Value of lung perfusion scintigraphy in patients with idiopathic pulmonary arterial hypertension: a patchy pattern to consider. Pulm Circ. 2019 Jan-Mar;9(1):2045894018816968. doi: 10.1177/2045894018816968. Epub 2018 Nov 15. PMID: 30430895; PMCID: PMC6295704.
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Pulm Circ. 2019 Jan-Mar;9(1):2045894018816968. doi: 10.1177/2045894018816968. Epub 2018 Nov 15.

Value of lung perfusion scintigraphy in patients with idiopathic pulmonary arterial hypertension: a patchy pattern to consider.

Pulmonary circulation

Meng Wang, Rongzheng Ma, Dayong Wu, Changming Xiong, Jianguo He, Lei Wang, Xiaoxin Sun, Wei Fang

Affiliations

  1. 1 Department of Nuclear Medicine, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  2. 2 Center for Diagnosis and Management of Pulmonary Vascular Diseases, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

PMID: 30430895 PMCID: PMC6295704 DOI: 10.1177/2045894018816968

Abstract

The ventilation/perfusion lung scan is recommended to exclude chronic thromboembolic pulmonary hypertension in the diagnostic algorithm of pulmonary hypertension, but its role in pulmonary arterial hypertension (PAH) has not been well explored. We characterized the lung perfusion pattern assessed by lung perfusion scintigraphy in idiopathic PAH (IPAH) patients and evaluate the potential prognostic significance of the patchy pattern perfusion defect. A total of 318 patients with IPAH confirmed by right heart catheterization who performed lung perfusion scintigraphy were included. On lung perfusion scintigraphy, 134 patients had normal lung perfusion and 184 patients showed patchy perfusion defects. In comparison to patients with normal lung perfusion, patients with patchy perfusion defects experienced significantly higher mean pulmonary arterial pressure (58.0 ± 15.4 mmHg vs. 54.1 ± 16.2 mmHg, P = 0.027) and total pulmonary resistance (1192.6 ± 533.7 dyn·s·cm

Keywords: idiopathic pulmonary arterial hypertension; lung blood flow; lung perfusion scintigraphy; prognosis

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