Display options
Cite
Maradonna F, Carnevali O. Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview. Front Endocrinol (Lausanne). 2018;9:654doi: 10.3389/fendo.2018.00654.
Maradonna, F., & Carnevali, O. (2018). Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview. Frontiers in endocrinology, 9654. https://doi.org/10.3389/fendo.2018.00654
Maradonna, Francesca, and Carnevali, Oliana. "Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview." Frontiers in endocrinology vol. 9 (2018): 654. doi: https://doi.org/10.3389/fendo.2018.00654
Maradonna F, Carnevali O. Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview. Front Endocrinol (Lausanne). 2018 Nov 08;9:654. doi: 10.3389/fendo.2018.00654. eCollection 2018. PMID: 30467492; PMCID: PMC6236061.
Copy Download .nbib Format: NLM
Share it on

Front Endocrinol (Lausanne). 2018 Nov 08;9:654. doi: 10.3389/fendo.2018.00654. eCollection 2018.

Lipid Metabolism Alteration by Endocrine Disruptors in Animal Models: An Overview.

Frontiers in endocrinology

Francesca Maradonna, Oliana Carnevali

Affiliations

  1. Dipartimento Scienze della Vita e dell'Ambiente, Università Politecnica delle Marche, Ancona, Italy.
  2. INBB Consorzio Interuniversitario di Biosistemi e Biostrutture, Rome, Italy.

PMID: 30467492 PMCID: PMC6236061 DOI: 10.3389/fendo.2018.00654

Abstract

Exposure to potential Endocrine Disrupting Chemicals (EDCs) pose a documented risk to both wildlife and human health. Many studies so far described declining sperm counts, genital malformations, early puberty onset, highlighting the negative impact on reproduction caused by the exposure to many anthropogenic chemicals. In the last years, increasing evidence suggested that these compounds, other than altering reproduction, affect metabolism and induce the onset of obesity and metabolic disorders. According to the "environmental obesogens" hypothesis, evidence exists that exposure to potential EDCs during critical periods when adipocytes are differentiating, and organs are developing, can induce diseases that manifest later in the life. This review summarizes the effects occurring at the hepatic level in different animal models, describing morphological alterations and changes of molecular pathways elicited by the toxicant exposure. Results currently available demonstrated that these chemicals impair normal metabolic processes via interaction with members of the nuclear receptor superfamily, including steroid hormone receptors, thyroid hormone receptors, retinoid X receptors, peroxisome proliferator-activated receptors, liver X receptors, and farnesoid X receptors. In addition, novel results revealed that EDC exposure can either affect circadian rhythms as well as up-regulate the expression of signals belonging to the endocannabinoid system, in both cases leading to a remarkable increase of lipid accumulation. These results warrant further research and increase the interest toward the identification of new mechanisms for EDC metabolic alterations. The last part of this review article condenses recent evidences on the ability of potential EDCs to cause "transgenerational effects" by a single prenatal or early life exposure. On this regard, there is compelling evidence that epigenetic modifications link developmental environmental insults to adult disease susceptibility. This review will contribute to summarize the mechanisms underlying the insurgence of EDC-induced metabolic alterations as well as to build integrated strategies for their better management. In fact, despite the large number of results obtained so far, there is still a great demand for the development of frameworks that can integrate mechanistic and toxicological/epidemiological observations. This would increase legal and governmental institution awareness on this critical environmental issue responsible for negative consequences in both wild species and human health.

Keywords: epigenetic; metabolic disorders; phthalates; reproduction; zebrafish (Danio rerio)

References

  1. Physiol Genomics. 2010 Mar 3;41(1):42-52 - PubMed
  2. Mol Endocrinol. 2009 Aug;23(8):1127-34 - PubMed
  3. Mol Cell Endocrinol. 2017 Dec 5;457:35-42 - PubMed
  4. Rev Endocr Metab Disord. 2007 Jun;8(2):161-71 - PubMed
  5. Sci Rep. 2018 Feb 19;8(1):3232 - PubMed
  6. Int J Mol Sci. 2018 Mar 08;19(3):null - PubMed
  7. Mol Cell Endocrinol. 2014 Dec;398(1-2):4-12 - PubMed
  8. Annu Rev Pharmacol Toxicol. 2016;56:251-72 - PubMed
  9. Gen Comp Endocrinol. 2017 May 1;245:122-126 - PubMed
  10. Mol Cell Biochem. 2014 Oct;395(1-2):145-54 - PubMed
  11. J Environ Sci (China). 2017 Dec;62:133-137 - PubMed
  12. Aquat Toxicol. 2017 Jul;188:148-158 - PubMed
  13. PPAR Res. 2014;2014:653017 - PubMed
  14. Environ Sci Eur. 2015;27(1):5 - PubMed
  15. PLoS One. 2013;8(1):e55387 - PubMed
  16. Toxicol In Vitro. 2013 Sep;27(6):1634-43 - PubMed
  17. Fish Physiol Biochem. 2015 Feb;41(1):1-18 - PubMed
  18. Nature. 1990 Oct 18;347(6294):645-50 - PubMed
  19. Toxicology. 2017 Sep 1;390:43-52 - PubMed
  20. Toxicol Lett. 2015 May 19;235(1):45-59 - PubMed
  21. Toxicol Appl Pharmacol. 2012 Jul 15;262(2):117-23 - PubMed
  22. Metabolism. 2016 Aug;65(8):1026-37 - PubMed
  23. Nutr Res. 2017 Aug;44:38-50 - PubMed
  24. J Neuroendocrinol. 2008 May;20 Suppl 1:124-9 - PubMed
  25. Chem Biol Interact. 2015 Mar 25;230:40-9 - PubMed
  26. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2053-2061 - PubMed
  27. Mol Endocrinol. 2006 Sep;20(9):2141-55 - PubMed
  28. Diabetes. 2004 Feb;53 Suppl 1:S43-50 - PubMed
  29. Environ Health Perspect. 2018 May 21;126(5):057006 - PubMed
  30. Prog Biophys Mol Biol. 2015 Jul;118(1-2):34-43 - PubMed
  31. Sci Rep. 2016 Feb 25;6:21982 - PubMed
  32. Comp Biochem Physiol B Biochem Mol Biol. 2005 Oct;142(2):224-32 - PubMed
  33. Curr Environ Health Rep. 2017 Jun;4(2):208-222 - PubMed
  34. Toxicol Lett. 2014 Mar 3;225(2):325-32 - PubMed
  35. Chemosphere. 2018 Aug;205:118-125 - PubMed
  36. Environ Pollut. 2017 Dec;231(Pt 1):1051-1062 - PubMed
  37. Sci Rep. 2018 Feb 1;8(1):2118 - PubMed
  38. Endocrinology. 2012 Sep;153(9):4097-110 - PubMed
  39. PLoS One. 2015 Dec 03;10(12):e0143911 - PubMed
  40. Sci Total Environ. 2018 Sep 15;636:641-655 - PubMed
  41. Biochim Biophys Acta. 2000 Dec 15;1529(1-3):103-13 - PubMed
  42. Steroids. 2010 Aug-Sep;75(8-9):585-94 - PubMed
  43. Toxicol Sci. 2016 Feb;149(2):396-410 - PubMed
  44. Dev Biol. 2013 Aug 15;380(2):259-73 - PubMed
  45. Genes (Basel). 2017 Oct 13;8(10):null - PubMed
  46. Environ Toxicol Pharmacol. 2016 Mar;42:38-44 - PubMed
  47. Toxicol Mech Methods. 2017 May;27(4):245-252 - PubMed
  48. J Biol Chem. 2018 May 18;293(20):7517-7521 - PubMed
  49. Environ Int. 2018 Oct;119:54-65 - PubMed
  50. Aquat Toxicol. 2017 Dec;193:256-267 - PubMed
  51. Trends Endocrinol Metab. 2015 Oct;26(10):564-572 - PubMed
  52. BMC Cancer. 2014 May 29;14:379 - PubMed
  53. Curr Top Med Chem. 2018;18(6):484-493 - PubMed
  54. PLoS One. 2014 Oct 27;9(10):e110706 - PubMed
  55. J Biol Chem. 1998 Dec 25;273(52):35299-306 - PubMed
  56. J Korean Med Sci. 2012 Jun;27(6):644-52 - PubMed
  57. Mol Pharmacol. 2005 Mar;67(3):766-74 - PubMed
  58. BMC Med. 2013 Oct 23;11:228 - PubMed
  59. Chem Res Toxicol. 2015 May 18;28(5):935-47 - PubMed
  60. Nat Rev Endocrinol. 2017 Dec;13(12):710-730 - PubMed
  61. Environ Epigenet. 2017 Oct 1;3(4):null - PubMed
  62. Front Endocrinol (Lausanne). 2018 Mar 28;9:123 - PubMed
  63. Endocr Rev. 2009 Oct;30(6):713-43 - PubMed
  64. Endocrinology. 2016 May;157(5):1751-63 - PubMed
  65. Int J Mol Sci. 2018 Jun 02;19(6):null - PubMed
  66. Nat Rev Endocrinol. 2010 Nov;6(11):629-36 - PubMed
  67. Aquat Toxicol. 2017 Apr;185:95-104 - PubMed
  68. Nat Rev Mol Cell Biol. 2006 Dec;7(12):885-96 - PubMed
  69. Environ Toxicol Pharmacol. 2017 Oct;55:87-93 - PubMed
  70. Br J Pharmacol. 2007 Nov;152(5):576-82 - PubMed
  71. Toxicology. 2012 Nov 15;301(1-3):40-9 - PubMed
  72. Oncotarget. 2017 Dec 18;8(70):115620-115631 - PubMed
  73. Acta Pharmacol Sin. 2014 Dec 15;36(1):88-101 - PubMed
  74. Semin Cell Dev Biol. 2012 Aug;23(6):631-9 - PubMed
  75. Endocrinology. 2015 Oct;156(10):3466-72 - PubMed
  76. Aquat Toxicol. 2015 Oct;167:257-64 - PubMed
  77. Mol Cell Endocrinol. 2010 Apr 29;318(1-2):61-8 - PubMed
  78. Horm Cancer. 2010 Jun;1(3):146-55 - PubMed
  79. Environ Sci Technol. 2014 Apr 1;48(7):4110-9 - PubMed
  80. Toxicol Lett. 2005 Dec 15;159(3):226-34 - PubMed
  81. Endocrinology. 2014 Aug;155(8):2770-80 - PubMed
  82. Environ Pollut. 2016 Nov;218:297-312 - PubMed
  83. PLoS One. 2016 Mar 04;11(3):e0150762 - PubMed
  84. Fish Physiol Biochem. 2018 Jun 11;:null - PubMed
  85. Endocrinology. 2017 Oct 1;158(10):3462-3476 - PubMed
  86. Reprod Toxicol. 2017 Mar;68:3-33 - PubMed
  87. PLoS One. 2014 Jul 24;9(7):e102091 - PubMed
  88. Toxicol Appl Pharmacol. 2017 Mar 15;319:22-38 - PubMed
  89. Comp Biochem Physiol C Toxicol Pharmacol. 2014 Nov;166:1-13 - PubMed
  90. Gen Comp Endocrinol. 2014 Sep 1;205:185-96 - PubMed
  91. Gen Comp Endocrinol. 2011 Feb 1;170(3):416-23 - PubMed
  92. Front Endocrinol (Lausanne). 2017 Oct 30;8:285 - PubMed
  93. Environ Toxicol. 2015 Dec;30(12):1434-44 - PubMed
  94. Biochim Biophys Acta. 2011 Aug;1812(8):1007-22 - PubMed

Publication Types