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Attaullah M, Yousuf MJ, Shaukat S, et al. Serum organochlorine pesticides residues and risk of cancer: A case-control study. Saudi J Biol Sci. 2017;25(7):1284-1290doi: 10.1016/j.sjbs.2017.10.023.
Attaullah, M., Yousuf, M. J., Shaukat, S., Anjum, S. I., Ansari, M. J., Buneri, I. D., Tahir, M., Amin, M., Ahmad, N., & Khan, S. U. (2018). Serum organochlorine pesticides residues and risk of cancer: A case-control study. Saudi journal of biological sciences, 25(7), 1284-1290. https://doi.org/10.1016/j.sjbs.2017.10.023
Attaullah, Mohammad, et al. "Serum organochlorine pesticides residues and risk of cancer: A case-control study." Saudi journal of biological sciences vol. 25,7 (2018): 1284-1290. doi: https://doi.org/10.1016/j.sjbs.2017.10.023
Attaullah M, Yousuf MJ, Shaukat S, Anjum SI, Ansari MJ, Buneri ID, Tahir M, Amin M, Ahmad N, Khan SU. Serum organochlorine pesticides residues and risk of cancer: A case-control study. Saudi J Biol Sci. 2018 Nov;25(7):1284-1290. doi: 10.1016/j.sjbs.2017.10.023. Epub 2017 Oct 17. PMID: 30505171; PMCID: PMC6252000.
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Saudi J Biol Sci. 2018 Nov;25(7):1284-1290. doi: 10.1016/j.sjbs.2017.10.023. Epub 2017 Oct 17.

Serum organochlorine pesticides residues and risk of cancer: A case-control study.

Saudi journal of biological sciences

Mohammad Attaullah, Masarrat J Yousuf, Sohail Shaukat, Syed Ishtiaq Anjum, Mohammad Javed Ansari, Islam Dad Buneri, Muhammad Tahir, Muhammad Amin, Naveed Ahmad, Shahid Ullah Khan

Affiliations

  1. Department of Zoology, Shaheed Benazir Bhutto University, Dir Upper, Pakistan.
  2. Department of Zoology, University of Karachi, Karachi, Pakistan.
  3. Center for Environmental Studies, Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, Pakistan.
  4. Department of Zoology, Kohat University of Science and Technology, Kohat, Pakistan.
  5. Bee Research Chair, Department of Plant Protection, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.
  6. Department of Botany, Hindu College Moradabad, M.J.P Rohilkhand University, 244001, India.
  7. Center of Excellence in Marine Biology, University of Karachi, Karachi 75270, Pakistan.
  8. College of Plant Sciences and Technology, Huazhong Agriculture University, Wuhan 430070, PR China.

PMID: 30505171 PMCID: PMC6252000 DOI: 10.1016/j.sjbs.2017.10.023

Abstract

Organochlorine pesticides (OCPs) are frequently used worldwide as insecticides, fungicides, herbicides and termiticides and have been associated with a variety of cancers in animal and human studies. In the present study, we examined residues of fourteen OCPs in the serum samples of diagnosed cancer patients and healthy residents of Karachi, Pakistan. A random collection of fasting blood samples was carried out from the donors with informed consent. Serum was separated within 2 h of blood collection and was then subjected to extraction with organic solvents followed by purification with florisil column. The final organic extract of each serum sample was processed with Gas Chromatograph coupled with Electron Capture Detector (GC-ECD). OCPs were detected in 97.59% of the cancer cases and 93.75% of the healthy subjects. Mean concentrations of total OCPs (ΣOCPs) was found elevated in the cancer group (0.606 mg/kg) compared with the control group (0.322 mg/kg). Endosulfan was the highest prevalent OCP with a mean concentration of 0.214 mg/kg in the cancer group and 0.166 mg/kg in the control group. The second most prevalent OCP was 4,4-DDE with a mean concentration of 0.131 mg/kg in the cancer group and 0.019 mg/kg in the control group. Highest level of ΣOCPs was detected in the breast cancer cases (20.411 mg/kg) with a mean level of (2.041 mg/kg). In light of the obtained results and available literature on the subject, it has been concluded that OCPs are positively associated with the risk of various cancers in humans.

Keywords: Cancer; DDE; Endosulfan; GC-ECD; Organochlorine pesticides; Serum

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