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Kianpour M, Aminorroaya A, Amini M, et al. Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population-based study Isfahan, Iran. J Res Med Sci. 2018;23:99doi: 10.4103/jrms.JRMS_197_18.
Kianpour, M., Aminorroaya, A., Amini, M., Feizi, A., & Janghorbani, M. (2018). Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population-based study Isfahan, Iran. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 2399. https://doi.org/10.4103/jrms.JRMS_197_18
Kianpour, Maryam, et al. "Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population-based study Isfahan, Iran." Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences vol. 23 (2018): 99. doi: https://doi.org/10.4103/jrms.JRMS_197_18
Kianpour M, Aminorroaya A, Amini M, Feizi A, Janghorbani M. Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population-based study Isfahan, Iran. J Res Med Sci. 2018 Nov 28;23:99. doi: 10.4103/jrms.JRMS_197_18. eCollection 2018. PMID: 30595707; PMCID: PMC6282545.
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J Res Med Sci. 2018 Nov 28;23:99. doi: 10.4103/jrms.JRMS_197_18. eCollection 2018.

Thyroid function test reference ranges in the first trimester of gestation and pregnancy outcomes: Protocol and preliminary results for cohort population-based study Isfahan, Iran.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

Maryam Kianpour, Ashraf Aminorroaya, Massoud Amini, Awat Feizi, Mohsen Janghorbani

Affiliations

  1. Isfahan Endocrine and Metabolism Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
  2. Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 30595707 PMCID: PMC6282545 DOI: 10.4103/jrms.JRMS_197_18

Abstract

BACKGROUND: This paper presents the protocol and primary findings of pregnancy cohort population-based study in Isfahan, Iran.

MATERIALS AND METHODS: In this cohort, 418 pregnant and 438 nonpregnant women were enrolled. In the first phase, serum concentrations of thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), thyroid peroxidase antibody, and urinary iodine concentration (UIC) were measured. Furthermore, the thyroid ultrasound was also performed. According to the results of thyroid function tests in the first phase, local reference range for TSH, FT4, and FT3 in pregnant and nonpregnant women are determined. The 2.5

RESULTS: The mean ± standard deviation for TSH, FT4, FT3, and UIC in the first trimester of gestation was 1.84 ± 1.32 mIU/L, 1.01 ± 0.15 ng/dL, 4.50 ± 0.64 pmol/L, and 172.0 ± 90.29 μg/L, respectively. In nonpregnant women, these values for TSH, FT4, FT3, and UIC were 2.58 ± 1.77 mIU/L, 1.10 ± 0.21 ng/dL, 4.49 ± 0.57 pmol/L, and 190.0 ± 109.6 μg/L, respectively.

CONCLUSION: The results of the present study could contribute to establish a local thyroid function tests reference ranges in the first trimester of pregnancy. It could possibly be effective on making a local reference value to prevent of thyroid disease misdiagnosis during pregnancy and adverse pregnancy outcomes.

Keywords: Cohort population-based study; Iran; pregnancy outcomes; reference range; thyroid function

Conflict of interest statement

There are no conflicts of interest.

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