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Witting M, Hastings J, Rodriguez N, et al. Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism . Front Mol Biosci. 2018;5:96doi: 10.3389/fmolb.2018.00096.
Witting, M., Hastings, J., Rodriguez, N., Joshi, C. J., Hattwell, J. P. N., Ebert, P. R., van Weeghel, M., Gao, A. W., Wakelam, M. J. O., Houtkooper, R. H., Mains, A., Le Novère, N., Sadykoff, S., Schroeder, F., Lewis, N. E., Schirra, H. J., Kaleta, C., & Casanueva, O. (2018). Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism . Frontiers in molecular biosciences, 596. https://doi.org/10.3389/fmolb.2018.00096
Witting, Michael, et al. "Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism ." Frontiers in molecular biosciences vol. 5 (2018): 96. doi: https://doi.org/10.3389/fmolb.2018.00096
Witting M, Hastings J, Rodriguez N, Joshi CJ, Hattwell JPN, Ebert PR, van Weeghel M, Gao AW, Wakelam MJO, Houtkooper RH, Mains A, Le Novère N, Sadykoff S, Schroeder F, Lewis NE, Schirra HJ, Kaleta C, Casanueva O. Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism . Front Mol Biosci. 2018 Nov 14;5:96. doi: 10.3389/fmolb.2018.00096. eCollection 2018. PMID: 30488036; PMCID: PMC6246695.
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Front Mol Biosci. 2018 Nov 14;5:96. doi: 10.3389/fmolb.2018.00096. eCollection 2018.

Modeling Meets Metabolomics-The WormJam Consensus Model as Basis for Metabolic Studies in the Model Organism .

Frontiers in molecular biosciences

Michael Witting, Janna Hastings, Nicolas Rodriguez, Chintan J Joshi, Jake P N Hattwell, Paul R Ebert, Michel van Weeghel, Arwen W Gao, Michael J O Wakelam, Riekelt H Houtkooper, Abraham Mains, Nicolas Le Novère, Sean Sadykoff, Frank Schroeder, Nathan E Lewis, Horst-Joachim Schirra, Christoph Kaleta, Olivia Casanueva

Affiliations

  1. Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum München, Neuherberg, Germany.
  2. Chair of Analytical Food Chemistry, Technische Universtität München, Freising, Germany.
  3. Epigenetics Department, Babraham Institute, Cambridge, United Kingdom.
  4. Department of Pediatrics, University of California, San Diego, La Jolla, CA, United States.
  5. Centre for Advanced Imaging, The University of Queensland, Brisbane, QLD, Australia.
  6. School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia.
  7. Laboratory Genetic Metabolic Diseases, Amsterdam UMC, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam Cardiovascular Sciences, Amsterdam, Netherlands.
  8. Signaling Department, Babraham Institute, Cambridge, United Kingdom.
  9. BTI/Cornell University, Ithaca, NY, United States.
  10. Novo Nordisk Foundation Center for Biosustainability at University of California, San Diego, La Jolla, CA, United States.
  11. Research Group Medical Systems Biology, Institute of Experimental Medicine, Christian-Albrechts-University Kiel, Kiel, Germany.

PMID: 30488036 PMCID: PMC6246695 DOI: 10.3389/fmolb.2018.00096

Abstract

Metabolism is one of the attributes of life and supplies energy and building blocks to organisms. Therefore, understanding metabolism is crucial for the understanding of complex biological phenomena. Despite having been in the focus of research for centuries, our picture of metabolism is still incomplete. Metabolomics, the systematic analysis of all small molecules in a biological system, aims to close this gap. In order to facilitate such investigations a blueprint of the metabolic network is required. Recently, several metabolic network reconstructions for the model organism

Keywords: Caenorhabditis elegans; metabolic pathways; metabolic reconstruction; metabolism; metabolomics

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