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Mboma J, Leblanc N, Wan S, et al. Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat. Food Sci Nutr. 2018;6(8):2092-2103doi: 10.1002/fsn3.766.
Mboma, J., Leblanc, N., Wan, S., Jacobs, R. L., Tchernof, A., Dubé, P., Angers, P., & Jacques, H. (2018). Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat. Food science & nutrition, 6(8), 2092-2103. https://doi.org/10.1002/fsn3.766
Mboma, Jean, et al. "Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat." Food science & nutrition vol. 6,8 (2018): 2092-2103. doi: https://doi.org/10.1002/fsn3.766
Mboma J, Leblanc N, Wan S, Jacobs RL, Tchernof A, Dubé P, Angers P, Jacques H. Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat. Food Sci Nutr. 2018 Oct 16;6(8):2092-2103. doi: 10.1002/fsn3.766. eCollection 2018 Nov. PMID: 30510710; PMCID: PMC6261175.
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Food Sci Nutr. 2018 Oct 16;6(8):2092-2103. doi: 10.1002/fsn3.766. eCollection 2018 Nov.

Liver and plasma lipid changes induced by cyclic fatty acid monomers from heated vegetable oil in the rat.

Food science & nutrition

Jean Mboma, Nadine Leblanc, Sereana Wan, René L Jacobs, André Tchernof, Pascal Dubé, Paul Angers, Hélène Jacques

Affiliations

  1. School of Nutrition Laval University Quebec City Quebec Canada.
  2. Institute of Nutrition and Functional Foods Laval University Quebec City Quebec Canada.
  3. Department of Biochemistry University of Alberta Edmonton Alberta Canada.
  4. Department of Agricultural, Food and Nutritional Science 4-002 Li Ka Shing Centre for Health Research Innovations University of Alberta Edmonton Alberta Canada.
  5. Quebec Heart and Lung Institute Quebec City Quebec Canada.
  6. Department of Food Science Laval University Quebec City Quebec Canada.

PMID: 30510710 PMCID: PMC6261175 DOI: 10.1002/fsn3.766

Abstract

Cyclic fatty acid monomers (CFAM) generated through domestic or industrial heating of vegetable oils may alter liver enzymes and induce hepatomegaly and steatosis, but the underlying mechanisms are not clearly understood. This study aimed to assess the effects of CFAM on liver and plasma lipids and to determine whether these effects are modulated by dietary lipids. Thirty-six (36) male Wistar rats were fed either of the four isoenergetic diets consisting of canola oil or soybean oil with/without 500 mg/100 g CFAM of total fat for 28 days. Rats fed CFAM had higher liver total lipids (

Keywords: cholesterol homeostasis; cyclic fatty acid monomers; fatty liver; male Wistar rats; phosphatidylcholine biosynthesis

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