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He YN, Zhang DK, Lin JZ, et al. Cardiac function evaluation for a novel one-step detoxification product of . Chin Med. 2018;13:62doi: 10.1186/s13020-018-0219-4.
He, Y. N., Zhang, D. K., Lin, J. Z., Han, X., Zhang, Y. M., Zhang, H. Z., Pei, J., Yang, M., & Wang, J. B. (2018). Cardiac function evaluation for a novel one-step detoxification product of . Chinese medicine, 1362. https://doi.org/10.1186/s13020-018-0219-4
He, Ya-Nan, et al. "Cardiac function evaluation for a novel one-step detoxification product of ." Chinese medicine vol. 13 (2018): 62. doi: https://doi.org/10.1186/s13020-018-0219-4
He YN, Zhang DK, Lin JZ, Han X, Zhang YM, Zhang HZ, Pei J, Yang M, Wang JB. Cardiac function evaluation for a novel one-step detoxification product of . Chin Med. 2018 Dec 17;13:62. doi: 10.1186/s13020-018-0219-4. eCollection 2018. PMID: 30568725; PMCID: PMC6297959.
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Chin Med. 2018 Dec 17;13:62. doi: 10.1186/s13020-018-0219-4. eCollection 2018.

Cardiac function evaluation for a novel one-step detoxification product of .

Chinese medicine

Ya-Nan He, Ding-Kun Zhang, Jun-Zhi Lin, Xue Han, Ya-Ming Zhang, Hai-Zhu Zhang, Jin Pei, Ming Yang, Jia-Bo Wang

Affiliations

  1. 1State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
  2. Sichuan Good Doctor Panxi Pharmaceutical Co., LTD, Xichang, China.
  3. 3Central Laboratory, Teaching Hospital of Chengdu University of TCM, Chengdu, People's Republic of China.
  4. 4China Military Institute of Chinese Medicine, 302 Military Hospital, No. 100 Xisihuan, Beijing, 100039 People's Republic of China.
  5. 5Department of Pharmacy and Chemistry, Dali University, Dali, People's Republic of China.
  6. 6Jiangxi University of Traditional Chinese Medicine, No. 18 Yunwan Avenue, Nanchang, 330004 People's Republic of China.

PMID: 30568725 PMCID: PMC6297959 DOI: 10.1186/s13020-018-0219-4

Abstract

METHODS: Initially, network pharmacology was applied to analyze the related pathways of candidate components acting on heart failure diseases. Then, two heart failure models that were induced by propafenone hydrochloride and nimodipine (v/v, 1:1) and were given doxorubicin were carried out to test the cardiac activity. Moreover, the effect on mitochondrial energy metabolism was further assessed.

RESULTS: Network pharmacology results indicated that

CONCLUSIONS: This study provides scientific evidence for the clinical application of new products. It is of great benefit to innovate the industrial detoxification process of Aconitum.

Keywords: Aconiti Lateralis Radix Praeparata; Cardiac function; Detoxification approach; Mitochondrial energy metabolism; Network pharmacology

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