J Cosmet Dermatol. 2019 Jan 01; doi: 10.1111/jocd.12850. Epub 2019 Jan 01.

Venoprotective drugs in pigmented purpuric dermatoses: A case report.

Journal of cosmetic dermatology

Aastha Gupta, Kabir Sardana, Ram Kishan Gautam

PMID: 30600593 DOI: 10.1111/jocd.12850

Abstract

Pigmented purpuric dermatoses (PPD) or capillaritis represent a benign condition, presenting with extravasation of erythrocytes in the skin and prominent hemosiderin deposition. The eruption runs a chronic relapsing course and is resistant to therapy. Capillary fragility, cellular immunity, and microvascular inflammation play important roles in the pathogenesis of PPD. Bioflavonoids, currently used as venoprotective agents for the management of chronic venous insufficiency, have been shown to reduce capillary fragility and permeability by inhibiting endothelial cell activation and modulating the leukocyte-endothelium interaction. We report a case of PPD with dramatic improvement consequent to a therapy with a fixed dose combination containing flavonoids like diosmin, hesperidin, and Euphorbia prostata extract along with calcium dobesilate.

© 2018 Wiley Periodicals, Inc.

Keywords: calcium dobesilate; micronized purified flavonoid fraction; pigmented purpuric dermatoses; venoactive drugs

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• Journal Article