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Mohabati D, van Dijk EH, van Rijssen TJ, et al. Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clin Ophthalmol. 2018;12:2167-2176doi: 10.2147/OPTH.S174573.
Mohabati, D., van Dijk, E. H., van Rijssen, T. J., de Jong, E. K., Breukink, M. B., Martinez-Ciriano, J. P., Dijkman, G., Hoyng, C. B., Fauser, S., Yzer, S., & Boon, C. J. (2018). Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clinical ophthalmology (Auckland, N.Z.), 122167-2176. https://doi.org/10.2147/OPTH.S174573
Mohabati, Danial, et al. "Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy." Clinical ophthalmology (Auckland, N.Z.) vol. 12 (2018): 2167-2176. doi: https://doi.org/10.2147/OPTH.S174573
Mohabati D, van Dijk EH, van Rijssen TJ, de Jong EK, Breukink MB, Martinez-Ciriano JP, Dijkman G, Hoyng CB, Fauser S, Yzer S, Boon CJ. Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy. Clin Ophthalmol. 2018 Oct 24;12:2167-2176. doi: 10.2147/OPTH.S174573. eCollection 2018. PMID: 30498331; PMCID: PMC6207264.
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Clin Ophthalmol. 2018 Oct 24;12:2167-2176. doi: 10.2147/OPTH.S174573. eCollection 2018.

Clinical spectrum of severe chronic central serous chorioretinopathy and outcome of photodynamic therapy.

Clinical ophthalmology (Auckland, N.Z.)

Danial Mohabati, Elon Hc van Dijk, Thomas J van Rijssen, Eiko K de Jong, Myrte B Breukink, Jose P Martinez-Ciriano, Greet Dijkman, Carel B Hoyng, Sascha Fauser, Suzanne Yzer, Camiel Jf Boon

Affiliations

  1. Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands, [email protected].
  2. Department of Ophthalmology, Rotterdam Ophthalmic Institute, Rotterdam, the Netherlands.
  3. Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands.
  4. Department of Ophthalmology, The Rotterdam Eye Hospital, Rotterdam, the Netherlands.
  5. Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany.
  6. Department of Ophthalmology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands, [email protected].

PMID: 30498331 PMCID: PMC6207264 DOI: 10.2147/OPTH.S174573

Abstract

PURPOSE: To describe a spectrum of severe chronic central serous chorioretinopathy (cCSC) cases and their response to photodynamic therapy (PDT).

PATIENTS AND METHODS: A total of 66 patients (81 eyes) with active severe cCSC were studied, and their response to PDT was compared with a control group consisting of 35 active cCSCs (37 eyes) that did not display characteristics of severity. Best-corrected visual acuity (BCVA) and complete resolution of subretinal fluid (SRF) were considered as main outcome measures.

RESULTS: In severe cCSC cases, we found cumulative areas of diffuse atrophic retinal pigment epithelium alterations in 48 eyes (59%), multiple "hot spots" of leakage in 36 eyes (44%), posterior cystoid retinal degeneration in 25 eyes (31%), and 13 eyes (16%) had a diffuse leakage on fluorescein angiography. After PDT treatment, BCVA increased in both groups, from 66 to 72 Early Treatment of Diabetic Retinopathy Study (ETDRS) letters in the case group (

CONCLUSION: A spectrum of severe cCSC exists, and PDT seems to be an effective treatment in both severe cCSC and nonsevere cCSC in terms of resolution of SRF. Final BCVA shows a significant improvement in both groups after PDT treatment.

Keywords: chronic central serous chorioretinopathy; photodynamic therapy; posterior cystoid retinal degeneration; severe phenotype; therapeutic outcome

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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