Display options
Cite
Avazpour N, Hajjari M, Yazdankhah S, et al. Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease. Genomics Inform. 2018;16(4):e25doi: 10.5808/GI.2018.16.4.e25.
Avazpour, N., Hajjari, M., Yazdankhah, S., Sahni, A., & Foroughmand, A. M. (2018). Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease. Genomics & informatics, 16(4), e25. https://doi.org/10.5808/GI.2018.16.4.e25
Avazpour, Niloofar, et al. "Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease." Genomics & informatics vol. 16,4 (2018): e25. doi: https://doi.org/10.5808/GI.2018.16.4.e25
Avazpour N, Hajjari M, Yazdankhah S, Sahni A, Foroughmand AM. Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease. Genomics Inform. 2018 Dec;16(4):e25. doi: 10.5808/GI.2018.16.4.e25. Epub 2018 Dec 28. PMID: 30602086; PMCID: PMC6440654.
Copy Download .nbib Format: NLM
Share it on

Genomics Inform. 2018 Dec;16(4):e25. doi: 10.5808/GI.2018.16.4.e25. Epub 2018 Dec 28.

Circulating HOTAIR RNA Is Potentially Up-regulated in Coronary Artery Disease.

Genomics & informatics

Niloofar Avazpour, Mohammadreza Hajjari, Saeed Yazdankhah, Azita Sahni, Ali Mohammad Foroughmand

Affiliations

  1. Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz 6135783151, Iran.
  2. Department of Cardiology, Ahvaz Jundishapur University of Medical Sciences, Imam Khomeini Hospital, Ahvaz 6135783151, Iran.

PMID: 30602086 PMCID: PMC6440654 DOI: 10.5808/GI.2018.16.4.e25

Abstract

Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as one of the main classes of cellular transcript play a key regulatory role in transcriptional and epigenetic pathways. Recent reports have demonstrated circulating long noncoding RNAs in blood can be potential biomarkers for CAD. HOTAIR is one of the most cited lncRNAs with a critical role in initiation and progression of the gene expression regulation. Recent research on the role of the HOTAIR in cardiovascular disease lays the basis for the development of new studies considering this lncRNA as a potential biomarker and therapeutic target in CAD. In this study, we aimed to compare the expression of HOTAIR lncRNA in the blood samples of patients with CAD and control samples. The expression level was examined by semi-quantitative reverse transcriptase polymerase chain reaction technique. Our data show that expression of HOTAIR is up-regulated in blood samples of patients with CAD.

Keywords: HOTAIR; coronary artery disease; gene expression; long noncoding RNA

References

  1. Cardiovasc Surg. 2001 Apr;9(2):109-21 - PubMed
  2. Circulation. 2001 Nov 27;104(22):2673-8 - PubMed
  3. Am J Cardiol. 2003 Feb 6;91(3A):3A-6A - PubMed
  4. Science. 2006 Feb 10;311(5762):796-800 - PubMed
  5. Nature. 2007 Jun 14;447(7146):799-816 - PubMed
  6. Cell. 2007 Jun 29;129(7):1311-23 - PubMed
  7. J Pathol. 2010 Jan;220(2):126-39 - PubMed
  8. Science. 2010 Aug 6;329(5992):689-93 - PubMed
  9. Cancer Lett. 2013 Oct 10;339(2):159-66 - PubMed
  10. PLoS One. 2013 Oct 29;8(10):e77938 - PubMed
  11. Trends Biochem Sci. 2014 Jan;39(1):35-43 - PubMed
  12. Nat Rev Cardiol. 2014 May;11(5):276-89 - PubMed
  13. PLoS One. 2014 May 01;9(5):e96577 - PubMed
  14. Tumour Biol. 2014 Nov;35(11):10645-63 - PubMed
  15. Biol Proced Online. 2014 Sep 15;16:11 - PubMed
  16. Lancet. 2015 Jan 10;385(9963):117-71 - PubMed
  17. J Mol Cell Cardiol. 2015 Jun;83:142-55 - PubMed
  18. Circ Res. 2015 Feb 13;116(4):751-62 - PubMed
  19. Cancer Biol Med. 2015 Mar;12(1):1-9 - PubMed
  20. Int J Cardiol. 2015 Jun 1;188:105-10 - PubMed
  21. Circ Res. 2015 Jul 3;117(2):192-206 - PubMed
  22. J Mol Cell Cardiol. 2015 Dec;89(Pt A):17-26 - PubMed
  23. Int J Mol Sci. 2015 Oct 05;16(10):23651-67 - PubMed
  24. Cardiovasc Res. 2016 Dec;112(3):714-724 - PubMed
  25. Genomics Proteomics Bioinformatics. 2016 Feb;14(1):42-54 - PubMed
  26. Atherosclerosis. 2016 May;248:51-61 - PubMed
  27. J Transl Med. 2016 Jun 18;14(1):183 - PubMed
  28. Int J Cardiol. 2017 Feb 1;228:570-582 - PubMed
  29. Circ Res. 2017 Jan 20;120(2):381-399 - PubMed
  30. Am J Hypertens. 2018 Jan 12;31(2):150-165 - PubMed
  31. Cell Physiol Biochem. 2017;44(4):1497-1508 - PubMed
  32. Front Cardiovasc Med. 2018 Mar 14;5:22 - PubMed

Publication Types