Display options
Cite
Manabe M, Tamagaki G, Shimizu K, et al. An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report. Am J Blood Res. 2018;8(3):17-20
Manabe, M., Tamagaki, G., Shimizu, K., Michimoto, K., Hagiwara, Y., Asada, R., Momose, D., Sugano, Y., Mazaki, T., & Koh, K. R. (2018). An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report. American journal of blood research, 8(3), 17-20.
Manabe, Masahiro, et al. "An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report." American journal of blood research vol. 8,3 (2018): 17-20.
Manabe M, Tamagaki G, Shimizu K, Michimoto K, Hagiwara Y, Asada R, Momose D, Sugano Y, Mazaki T, Koh KR. An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report. Am J Blood Res. 2018 Oct 05;8(3):17-20. eCollection 2018. PMID: 30498621; PMCID: PMC6261837.
Copy Download .nbib Format: NLM
Share it on

Am J Blood Res. 2018 Oct 05;8(3):17-20. eCollection 2018.

An isolated der(1;21)(q10;q10) translocation in a patient with myelodysplastic syndrome: a case report.

American journal of blood research

Masahiro Manabe, Gakuya Tamagaki, Keiji Shimizu, Koichi Michimoto, Yuuji Hagiwara, Reiko Asada, Dai Momose, Yasuyoshi Sugano, Takeshi Mazaki, Ki-Ryang Koh

Affiliations

  1. Osaka General Hospital of West Japan Railway Company 1-2-22 Matsuzaki-cho, Abeno-ku, Osaka 545-0053, Japan.

PMID: 30498621 PMCID: PMC6261837

Abstract

Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on myeloid malignancies harboring der(1;21)(q10;q10). A 65-year-old male was referred to our hospital due to squamous cell carcinoma of the lung. Pembrolizumab monotherapy resulted in progression, and so chemotherapy involving nab-paclitaxel and carboplatin was administered thereafter. The patient developed cytopenia, and his bone marrow exhibited dysplasia. Chromosomal analysis revealed a whole-arm translocation, der(1;21)(q10;q10). Thus, the patient was diagnosed with myelodysplastic syndrome. The der(1;21)(q10;q10) translocation is a rare variant of the der(1;7)(q10;p10) translocation, which is an adverse prognostic factor for myeloid neoplasms. Clarifying the clinical features of myeloid neoplasms in patients with der(1;21)(q10;q10) would facilitate the elucidation of their tumorigenic mechanisms.

Keywords: der(1;21)(q10;q10); myelodysplastic syndrome; whole-arm translocation

Conflict of interest statement

None.

References

  1. Genomics. 1996 Dec 15;38(3):325-30 - PubMed
  2. Leuk Lymphoma. 1999 Oct;35(3-4):311-5 - PubMed
  3. Leukemia. 1998 May;12(5):801-4 - PubMed
  4. Br J Pharmacol. 2011 Feb;162(4):792-805 - PubMed
  5. Blood. 2003 Oct 1;102(7):2597-604 - PubMed
  6. Genes Chromosomes Cancer. 1995 Sep;14(1):56-62 - PubMed
  7. Cancer Genet Cytogenet. 2006 Mar;165(2):161-6 - PubMed
  8. Am J Hematol. 1986 Jun;22(2):155-67 - PubMed
  9. Cancer Genet Cytogenet. 2007 Mar;173(2):136-43 - PubMed
  10. Genes Chromosomes Cancer. 2000 Aug;28(4):415-24 - PubMed
  11. Leukemia. 2007 May;21(5):992-7 - PubMed
  12. Leukemia. 2002 Dec;16(12):2366-78 - PubMed
  13. Nucleic Acids Res. 1993 May 11;21(9):2209-15 - PubMed

Publication Types