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Badry R, Gamal RM, Hassanien MM, et al. Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis. Egypt J Neurol Psychiatr Neurosurg. 2018;54(1):38doi: 10.1186/s41983-018-0044-9.
Badry, R., Gamal, R. M., Hassanien, M. M., El Hamed, M. A., Hammam, N., & El Fawal, B. M. (2018). Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis. The Egyptian journal of neurology, psychiatry and neurosurgery, 54(1), 38. https://doi.org/10.1186/s41983-018-0044-9
Badry, Reda, et al. "Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis." The Egyptian journal of neurology, psychiatry and neurosurgery vol. 54,1 (2018): 38. doi: https://doi.org/10.1186/s41983-018-0044-9
Badry R, Gamal RM, Hassanien MM, El Hamed MA, Hammam N, El Fawal BM. Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis. Egypt J Neurol Psychiatr Neurosurg. 2018;54(1):38. doi: 10.1186/s41983-018-0044-9. Epub 2018 Nov 27. PMID: 30546249; PMCID: PMC6267634.
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Egypt J Neurol Psychiatr Neurosurg. 2018;54(1):38. doi: 10.1186/s41983-018-0044-9. Epub 2018 Nov 27.

Sympathetic skin response in patients with systemic sclerosis and rheumatoid arthritis.

The Egyptian journal of neurology, psychiatry and neurosurgery

Reda Badry, Rania M Gamal, Manal M Hassanien, Mohamed Abd El Hamed, Nevin Hammam, Bastawy M El Fawal

Affiliations

  1. 1Department of Neurology and Psychiatry, Assiut University Hospital, Post Box: 711526, Assiut, Egypt.
  2. 2Rheumatology and Rehabilitation Department, Assiut University Hospital, Assiut, Egypt.
  3. 3Department of Neurology and Psychiatry, Aswan University Hospital, Aswan, Egypt.

PMID: 30546249 PMCID: PMC6267634 DOI: 10.1186/s41983-018-0044-9

Abstract

BACKGROUND: Sympathetic skin response (SSR) is a technique to assess the sympathetic cholinergic pathways. Sympathetic dysfunction may participate in the development of pain, which is the major complaint in patients with systemic sclerosis (SSc) and rheumatoid arthritis (RA).

OBJECTIVES: In this study, we aimed to assess the autonomic dysfunction in patients with (SSc) and (RA) using SSR as a simple neurophysiologic test.

METHODS: Palmar SSR to median nerve electrical stimulation was recorded in 21 patients with SSc, 39 patients with RA, and in 60 healthy age and sex-matched control subjects.

RESULTS: Palmar SSR to median nerve stimulation (of SSc patients and RA patients) shows significantly delayed latency and reduced amplitude in comparison to the control group. SSR of SSc patients has significantly delayed latency and reduced amplitude when compared to RA patients. Moreover, six SSc patients have delayed SSR in spite of the absence of manifestations of polyneuropathy.

CONCLUSIONS: Patients with SSc and RA have features of autonomic dysfunction with more affection of SSc patients.

Keywords: Autonomic dysfunction (AD); Rheumatoid arthritis (RA); Sympathetic skin response (SSR); Systemic sclerosis (SSc)

Conflict of interest statement

A written consent was taken from all of the participants after explaining the details, benefits as well as risks to them. The study was approved from the institutional ethics committee of the Faculty

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