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Srivastava N, Nandi I, Ibeyaima A, et al. Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds. 3 Biotech. 2019;9(1):27doi: 10.1007/s13205-018-1556-9.
Srivastava, N., Nandi, I., Ibeyaima, A., Gupta, S., & Sarethy, I. P. (2019). Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds. 3 Biotech, 9(1), 27. https://doi.org/10.1007/s13205-018-1556-9
Srivastava, Nidhi, et al. "Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds." 3 Biotech vol. 9,1 (2019): 27. doi: https://doi.org/10.1007/s13205-018-1556-9
Srivastava N, Nandi I, Ibeyaima A, Gupta S, Sarethy IP. Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds. 3 Biotech. 2019 Jan;9(1):27. doi: 10.1007/s13205-018-1556-9. Epub 2019 Jan 02. PMID: 30622865; PMCID: PMC6314948.
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3 Biotech. 2019 Jan;9(1):27. doi: 10.1007/s13205-018-1556-9. Epub 2019 Jan 02.

Microbial diversity of a Himalayan forest and characterization of rare actinomycetes for antimicrobial compounds.

3 Biotech

Nidhi Srivastava, Ipsita Nandi, Ahongshangbam Ibeyaima, Sanjay Gupta, Indira P Sarethy

Affiliations

  1. Department of Biotechnology, Jaypee Institute of Information Technology, A-10, Sector-62, Noida, 201309 India.

PMID: 30622865 PMCID: PMC6314948 DOI: 10.1007/s13205-018-1556-9

Abstract

The slow pace of discovery of new effective drugs against multi-drug resistant pathogens and largely unsuccessful combinatorial chemistry has resulted in shifting the focus back to natural products as sources of lead molecules for antimicrobial drugs, mainly due to their structural diversity. Investigation of under-explored habitats for potentially novel microorganisms provides for wider chemodiversity. In this study, four actinomycetes, namely UK-274, UK-281, UK-282 and UK-285, which showed broad-spectrum antibacterial and antifungal activities, were isolated from Timli forest range of the biodiversity-rich Himalayan region. 16S rRNA gene sequence analysis showed that the nearest neighbours of the isolates were

Keywords: Actinomycete; Antimicrobial; Forest; Metabolite fingerprinting; Multi-drug resistant; Natural products

Conflict of interest statement

On the behalf of all authors, corresponding author states that there is no conflict of interest.This article does not contain any studies with human or animal subjects.

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