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Zhu Y, Liu H, Xie N, et al. Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis. Head Neck. 2018;41(2):542-550doi: 10.1002/hed.25462.
Zhu, Y., Liu, H., Xie, N., Liu, X., Huang, H., Wang, C., & Hou, J. (2019). Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis. Head & neck, 41(2), 542-550. https://doi.org/10.1002/hed.25462
Zhu, Yue, et al. "Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis." Head & neck vol. 41,2 (2019): 542-550. doi: https://doi.org/10.1002/hed.25462
Zhu Y, Liu H, Xie N, Liu X, Huang H, Wang C, Hou J. Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis. Head Neck. 2019 Feb;41(2):542-550. doi: 10.1002/hed.25462. Epub 2018 Dec 14. PMID: 30549142.
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Head Neck. 2019 Feb;41(2):542-550. doi: 10.1002/hed.25462. Epub 2018 Dec 14.

Impact of tumor budding in head and neck squamous cell carcinoma: A meta-analysis.

Head & neck

Yue Zhu, Haichao Liu, Nan Xie, Xiqiang Liu, Hongzhang Huang, Cheng Wang, Jinsong Hou

Affiliations

  1. Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.
  2. Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
  3. Department of Oral Patholgoy, Guanghua School of Stomatology, Hospital of Stomatology, Guangzhou, China.

PMID: 30549142 DOI: 10.1002/hed.25462

Abstract

Tumor budding (TB) has been suggested as an adverse prognostic factor in head and neck squamous cell carcinoma (HNSCC). This meta-analysis evaluated the prognostic role of TB in HNSCC. We systematically reviewed the literatures of electronic databases and performed a meta-analysis to address the impact of TB on prognosis in HNSCC. Published data were extracted and organized. Then, pooled odds ratios for lymph node metastasis (LNM) and hazard ratios for survival were calculated by using the Mantel-Haenszel fixed effect model. The results showed that high TB was significantly associated with LNM and worse survival in patients with HNSCC. Moreover, high TB was also correlated with poor prognosis in patients with cT1-2N0 oral squamous cell carcinoma. TB is a promising prognostic factor associated with LNM and worse survival, which should be included in the routine pathological examination of HNSCC.

© 2018 Wiley Periodicals, Inc.

Keywords: head and neck squamous cell carcinoma; lymph node metastasis; prognostic factor; survival; tumor budding

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