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Voynova E, Mahmoud T, Woods LT, et al. Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways. Immunohorizons. 2018;2(1):54-66doi: 10.4049/immunohorizons.1700069.
Voynova, E., Mahmoud, T., Woods, L. T., Weisman, G. A., Ettinger, R., & Braley-Mullen, H. (2018). Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways. ImmunoHorizons, 2(1), 54-66. https://doi.org/10.4049/immunohorizons.1700069
Voynova, Elisaveta, et al. "Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways." ImmunoHorizons vol. 2,1 (2018): 54-66. doi: https://doi.org/10.4049/immunohorizons.1700069
Voynova E, Mahmoud T, Woods LT, Weisman GA, Ettinger R, Braley-Mullen H. Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways. Immunohorizons. 2018 Jan 01;2(1):54-66. doi: 10.4049/immunohorizons.1700069. PMID: 30607385; PMCID: PMC6309431.
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Immunohorizons. 2018 Jan 01;2(1):54-66. doi: 10.4049/immunohorizons.1700069.

Requirement for CD40/CD40L Interactions for Development of Autoimmunity Differs Depending on Specific Checkpoint and Costimulatory Pathways.

ImmunoHorizons

Elisaveta Voynova, Tamer Mahmoud, Lucas T Woods, Gary A Weisman, Rachel Ettinger, Helen Braley-Mullen

Affiliations

  1. Respiratory, Inflammation and Autoimmunity Group, Medimmune LLC, Gaithersburg, MD 20878.
  2. Department of Biochemistry, Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211.
  3. Department of Medicine and Microbiology, University of Missouri, Columbia, MO 65212.

PMID: 30607385 PMCID: PMC6309431 DOI: 10.4049/immunohorizons.1700069

Abstract

CD40/CD40L interactions play a critical role in immunity and autoimmunity. In this study, we sought to understand the requirement for CD40 signaling in the programmed cell death-1 (PD-1) checkpoint and CD28 costimulatory pathways important for maintenance of peripheral tolerance. Blocking either pathway can result in loss of self-tolerance and development of autoimmunity. We found that primary Sjögren's syndrome (pSS) and autoimmune thyroid diseases (ATDs) that develop spontaneously in CD28-deficient IFN-γ

References

  1. J Autoimmun. 1999 Feb;12(1):1-12 - PubMed
  2. J Exp Med. 1999 Oct 18;190(8):1115-22 - PubMed
  3. J Immunol. 2000 Dec 15;165(12):7262-9 - PubMed
  4. Nat Rev Immunol. 2002 Feb;2(2):116-26 - PubMed
  5. J Clin Immunol. 2002 Jan;22(1):1-7 - PubMed
  6. Science. 2002 Sep 20;297(5589):2006-8 - PubMed
  7. Science. 2002 Sep 20;297(5589):2066-70 - PubMed
  8. J Immunol. 2002 Oct 1;169(7):3999-4007 - PubMed
  9. J Exp Med. 2003 Jul 7;198(1):63-9 - PubMed
  10. J Clin Invest. 2004 Oct;114(7):979-87 - PubMed
  11. Annu Rev Immunol. 2005;23:515-48 - PubMed
  12. Clin Immunol. 2006 Jan;118(1):92-100 - PubMed
  13. J Exp Med. 2006 Nov 27;203(12):2737-47 - PubMed
  14. Nat Immunol. 2007 Mar;8(3):239-45 - PubMed
  15. Xenotransplantation. 2007 May;14(3):243-8 - PubMed
  16. Clin Rheumatol. 2007 Oct;26(10):1601-6 - PubMed
  17. Annu Rev Immunol. 2008;26:677-704 - PubMed
  18. J Immunol. 2008 Jun 1;180(11):7706-13 - PubMed
  19. J Exp Med. 2008 Nov 24;205(12):2873-86 - PubMed
  20. Immunol Rev. 2009 May;229(1):41-66 - PubMed
  21. Immunol Rev. 2009 May;229(1):152-72 - PubMed
  22. Ann N Y Acad Sci. 2009 Sep;1173:378-83 - PubMed
  23. J Autoimmun. 2009 Nov-Dec;33(3-4):190-6 - PubMed
  24. Nat Rev Immunol. 2009 Dec;9(12):845-57 - PubMed
  25. J Exp Med. 2009 Dec 21;206(13):3015-29 - PubMed
  26. Nat Immunol. 2010 Jun;11(6):535-42 - PubMed
  27. Lab Invest. 2011 Jan;91(1):54-62 - PubMed
  28. J Immunol. 2011 Feb 15;186(4):2655-62 - PubMed
  29. Blood. 2011 May 19;117(20):5532-40 - PubMed
  30. J Immunol. 2011 May 15;186(10):5648-55 - PubMed
  31. Arthritis Res Ther. 2011 Jun 13;13(3):217 - PubMed
  32. J Immunol. 2011 Nov 1;187(9):4421-5 - PubMed
  33. J Exp Med. 2012 Mar 12;209(3):597-606 - PubMed
  34. Chimerism. 2011 Oct-Dec;2(4):111-3 - PubMed
  35. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10468-73 - PubMed
  36. J Immunol. 2012 Sep 15;189(6):3043-53 - PubMed
  37. Immunology. 2013 Jun;139(2):179-86 - PubMed
  38. J Immunol. 2013 Apr 15;190(8):3928-38 - PubMed
  39. Scand J Immunol. 2013 Aug;78(2):157-66 - PubMed
  40. PLoS One. 2013 May 23;8(5):e64878 - PubMed
  41. Crit Rev Immunol. 2013;33(4):361-78 - PubMed
  42. J Immunol. 2013 Nov 15;191(10):4940-9 - PubMed
  43. PLoS One. 2014 Feb 28;9(2):e89561 - PubMed
  44. Eur J Immunol. 2014 May;44(5):1258-64 - PubMed
  45. Mol Immunol. 2014 Dec;62(2):277-82 - PubMed
  46. Eur J Immunol. 2014 Sep;44(9):2603-16 - PubMed
  47. J Immunol. 2014 Aug 15;193(4):1609-21 - PubMed
  48. PLoS One. 2014 Aug 07;9(8):e102791 - PubMed
  49. Eur J Immunol. 2014 Dec;44(12):3560-72 - PubMed
  50. Immunology. 2015 Apr;144(4):598-610 - PubMed
  51. Elife. 2014 Oct 27;3:null - PubMed
  52. Immun Inflamm Dis. 2013 Oct;1(1):14-25 - PubMed
  53. Adv Immunol. 2015;126:1-43 - PubMed
  54. Int Immunol. 2016 Apr;28(4):173-9 - PubMed
  55. Cell. 2016 Apr 7;165(2):272-5 - PubMed
  56. Immunol Rev. 2016 May;271(1):246-59 - PubMed
  57. Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8490-5 - PubMed
  58. J Immunol. 2016 Sep 15;197(6):2119-30 - PubMed
  59. Nat Rev Rheumatol. 2016 Oct;12(10):593-604 - PubMed
  60. Nat Immunol. 2016 Dec;17(12):1436-1446 - PubMed
  61. Sci Transl Med. 2016 Oct 19;8(361):361ra137 - PubMed
  62. N Engl J Med. 2016 Nov 03;375(18):1749-1755 - PubMed
  63. Rheum Dis Clin North Am. 2017 Feb;43(1):65-78 - PubMed
  64. Cell. 2016 Dec 1;167(6):1540-1554.e12 - PubMed
  65. Nat Rev Endocrinol. 2017 Apr;13(4):195-207 - PubMed
  66. J Clin Med. 2017 Jan 26;6(2): - PubMed
  67. RMD Open. 2017 Mar 20;3(1):e000412 - PubMed
  68. Immunol Cell Biol. 2017 Sep;95(8):684-694 - PubMed
  69. Cell. 2017 Sep 7;170(6):1120-1133.e17 - PubMed
  70. J Immunol. 1994 Jun 15;152(12):5643-52 - PubMed
  71. J Immunol. 1996 Jun 15;156(12):4576-81 - PubMed
  72. Immunology. 1997 Mar;90(3):421-6 - PubMed
  73. J Immunol. 1997 Nov 1;159(9):4620-7 - PubMed
  74. Annu Rev Immunol. 1998;16:111-35 - PubMed
  75. J Clin Invest. 1999 Jan;103(2):281-90 - PubMed

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