Display options
Cite
Mathiesen JS, Kroustrup JP, Vestergaard P, et al. Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study. Endocr Connect. 2019;8(1):1-7doi: 10.1530/EC-18-0494.
Mathiesen, J. S., Kroustrup, J. P., Vestergaard, P., Poulsen, P. L., Rasmussen, �. �. K., Feldt-Rasmussen, U., Schytte, S., Londero, S. C., Pedersen, H. B., Hahn, C. H., Bentzen, J., Möller, S., Gaustadnes, M., Rossing, M., Nielsen, F. C., Brixen, K., & Godballe, C. (2019). Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study. Endocrine connections, 8(1), 1-7. https://doi.org/10.1530/EC-18-0494
Mathiesen, Jes Sloth, et al. "Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study." Endocrine connections vol. 8,1 (2019): 1-7. doi: https://doi.org/10.1530/EC-18-0494
Mathiesen JS, Kroustrup JP, Vestergaard P, Poulsen PL, Rasmussen ÅK, Feldt-Rasmussen U, Schytte S, Londero SC, Pedersen HB, Hahn CH, Bentzen J, Möller S, Gaustadnes M, Rossing M, Nielsen FC, Brixen K, Godballe C. Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study. Endocr Connect. 2019 Jan 01;8(1):1-7. doi: 10.1530/EC-18-0494. PMID: 30550378; PMCID: PMC6330714.
Copy Download .nbib Format: NLM
Share it on

Endocr Connect. 2019 Jan 01;8(1):1-7. doi: 10.1530/EC-18-0494.

Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.

Endocrine connections

Jes Sloth Mathiesen, Jens Peter Kroustrup, Peter Vestergaard, Per Løgstrup Poulsen, Åse Krogh Rasmussen, Ulla Feldt-Rasmussen, Sten Schytte, Stefano Christian Londero, Henrik Baymler Pedersen, Christoffer Holst Hahn, Jens Bentzen, Sören Möller, Mette Gaustadnes, Maria Rossing, Finn Cilius Nielsen, Kim Brixen, Christian Godballe

Affiliations

  1. Department of ORL Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.
  2. Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
  3. Department of Clinical Medicine and Endocrinology, Aalborg University Hospital, Aalborg, Denmark.
  4. Steno Diabetes Center North Jutland, Aalborg, Denmark.
  5. Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark.
  6. Department of Medical Endocrinology, Copenhagen University Hospital, Copenhagen, Denmark.
  7. Department of ORL Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark.
  8. Department of ORL Head & Neck Surgery, Aalborg University Hospital, Aalborg, Denmark.
  9. Department of ORL Head & Neck Surgery, Copenhagen University Hospital, Copenhagen, Denmark.
  10. Department of Oncology, Herlev Hospital, Herlev, Denmark.
  11. Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.
  12. Department of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.
  13. Center for Genomic Medicine, Copenhagen University Hospital, Copenhagen, Denmark.

PMID: 30550378 PMCID: PMC6330714 DOI: 10.1530/EC-18-0494

Abstract

A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. This retrospective cohort study included 191 patients identified from the nationwide Danish MTC cohort between 1997 and 2014. In multivariate analysis, hazard ratios for overall survival under the current AJCC TNM staging system vs the proposed TNM groupings with stage I as reference were 1.32 (95% CI: 0.38-4.57) vs 3.04 (95% CI: 1.38-6.67) for stage II, 2.06 (95% CI: 0.45-9.39) vs 3.59 (95% CI: 1.61-8.03) for stage III and 5.87 (95% CI: 2.02-17.01) vs 59.26 (20.53-171.02) for stage IV. The newly proposed TNM groupings appear to provide better survival discrimination in the nationwide Danish MTC cohort than the current AJCC TNM staging. Adaption of the proposed TNM groupings by the current AJCC TNM staging system may potentially improve accurateness in survival discrimination. However, before such an adaption further population-based studies securing external validity are needed.

Keywords: endocrine cancers; rare diseases/syndromes; thyroid

References

  1. Scand J Public Health. 2011 Jul;39(7 Suppl):72-4 - PubMed
  2. BMJ. 1995 Jan 21;310(6973):170 - PubMed
  3. Henry Ford Hosp Med J. 1984;32(4):238-43 - PubMed
  4. Oral Oncol. 2013 Jul;49(7):695-701 - PubMed
  5. Oncotarget. 2016 Mar 29;7(13):15937-47 - PubMed
  6. Endocr Relat Cancer. 2017 Jul;24(7):L39-L42 - PubMed
  7. Endocr Connect. 2018 Jun;7(6):829-839 - PubMed
  8. JAMA Surg. 2017 Sep 1;152(9):869-876 - PubMed
  9. Thyroid. 2017 Feb;27(2):215-223 - PubMed
  10. JAMA Surg. 2018 Jun 1;153(6):588-589 - PubMed
  11. Cancer. 1997 Feb 1;79(3):564-73 - PubMed
  12. Arch Surg. 2009 Jul;144(7):663-9 - PubMed
  13. Clin Endocrinol (Oxf). 1998 Mar;48(3):265-73 - PubMed
  14. Thyroid. 2017 May;27(5):626-631 - PubMed
  15. Ann Surg. 2013 Feb;257(2):323-9 - PubMed
  16. Cancer Epidemiol. 2014 Oct;38(5):633-7 - PubMed
  17. Cancer. 2000 Aug 15;89(4):863-7 - PubMed
  18. Surgery. 2018 Feb;163(2):361-366 - PubMed
  19. Cancer. 2006 Nov 1;107(9):2134-42 - PubMed
  20. Ugeskr Laeger. 2014 Jan 27;176(5A): - PubMed
  21. J Clin Endocrinol Metab. 2017 Jun 1;102(6):2069-2074 - PubMed
  22. Scand J Public Health. 2011 Jul;39(7 Suppl):42-5 - PubMed
  23. Langenbecks Arch Surg. 1998 Oct;383(5):334-6 - PubMed
  24. Gland Surg. 2016 Aug;5(4):398-404 - PubMed
  25. Clin Epidemiol. 2018 Oct 12;10:1479-1487 - PubMed
  26. Eur Arch Otorhinolaryngol. 2010 Apr;267(4):613-7 - PubMed
  27. Acta Ophthalmol Scand. 2007 Feb;85(1):120-1 - PubMed
  28. JAMA Surg. 2018 Sep 1;153(9):850-851 - PubMed
  29. Thyroid. 2017 Dec;27(12):1505-1510 - PubMed
  30. J Clin Endocrinol Metab. 2014 Feb;99(2):448-54 - PubMed
  31. Cancer. 2016 Feb 1;122(3):358-66 - PubMed
  32. JAMA Surg. 2018 Jan 1;153(1):52-59 - PubMed
  33. Thyroid. 2019 Mar;29(3):368-377 - PubMed
  34. Thyroid. 2015 Jan;25(1):139-40 - PubMed

Publication Types