Display options
Cite
Izzo V, Greco C, Corradini D, et al. Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018;6:2050313X18819601doi: 10.1177/2050313X18819601.
Izzo, V., Greco, C., Corradini, D., Infante, M., Staltari, M. T., Romano, M., Bellia, A., Lauro, D., & Uccioli, L. (2018). Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature. SAGE open medical case reports, 62050313X18819601. https://doi.org/10.1177/2050313X18819601
Izzo, Valentina, et al. "Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature." SAGE open medical case reports vol. 6 (2018): 2050313X18819601. doi: https://doi.org/10.1177/2050313X18819601
Izzo V, Greco C, Corradini D, Infante M, Staltari MT, Romano M, Bellia A, Lauro D, Uccioli L. Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature. SAGE Open Med Case Rep. 2018 Dec 26;6:2050313X18819601. doi: 10.1177/2050313X18819601. eCollection 2018. PMID: 30627435; PMCID: PMC6311546.
Copy Download .nbib Format: NLM
Share it on

SAGE Open Med Case Rep. 2018 Dec 26;6:2050313X18819601. doi: 10.1177/2050313X18819601. eCollection 2018.

Insulin autoimmune syndrome in an Argentine woman taking α-lipoic acid: A case report and review of the literature.

SAGE open medical case reports

Valentina Izzo, Carla Greco, Diana Corradini, Marco Infante, Maria Teresa Staltari, Maria Romano, Alfonso Bellia, Davide Lauro, Luigi Uccioli

Affiliations

  1. Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.

PMID: 30627435 PMCID: PMC6311546 DOI: 10.1177/2050313X18819601

Abstract

Insulin autoimmune syndrome is an unusual cause of spontaneous hypoglycaemia in non-Asian populations. In the majority of cases, this syndrome appears a few weeks after the administration of drugs containing a sulfhydryl group. A strong association between this syndrome and HLA-DR4 has been shown. Only seven cases have been described in non-Asian patients. We report the first case of insulin autoimmune syndrome in an Argentine woman taking alfa-lipoic acid. She developed hypoglycaemic symptoms approximately 1 month after starting therapy. Blood sampling collected during an episode of symptomatic hypoglycaemia showed low blood glucose level (2.39 mmol/L), high level of serum insulin (1971.55 pmol/L), inappropriately high level of C-peptide (2.36 nmol/L) and high levels of insulin antibodies (274.78 IU/mL). HLA-DNA typing identified DRB1*04:03. Due to the widespread use of alfa-lipoic acid for its antioxidant properties, clinicians should be aware that it may trigger an autoimmune hypoglycaemia in people with a genetic predisposition.

Keywords: Hirata disease; Insulin autoimmune syndrome; alfa-lipoic acid; antibodies; hypoglycaemia

Conflict of interest statement

Declaration of conflicting interests: The author(s) declare no potential conflict of interest with respect to the research, authorship and publication of the article.

References

  1. Ann Clin Biochem. 1999 Sep;36 ( Pt 5):541-64 - PubMed
  2. Ann Med Interne (Paris). 2003 Feb;154(1):59-60 - PubMed
  3. Lancet. 1992 Feb 15;339(8790):393-4 - PubMed
  4. Diabetes Res Clin Pract. 2007 Mar;75(3):366-7 - PubMed
  5. Diabetes Care. 2006 Nov;29(11):2365-70 - PubMed
  6. Intern Med. 2007;46(5):237-9 - PubMed
  7. Diabetes Care. 2007 Sep;30(9):2240-1 - PubMed
  8. Intern Med. 2007;46(17):1321-2 - PubMed
  9. Diabetes Care. 2007 Dec;30(12):e131 - PubMed
  10. Diabetes Res Clin Pract. 2009 Jan;83(1):e19-20 - PubMed
  11. J Clin Endocrinol Metab. 2009 Mar;94(3):709-28 - PubMed
  12. Medicine (Baltimore). 2009 May;88(3):141-53 - PubMed
  13. Nucleic Acids Res. 2011 Jan;39(Database issue):D913-9 - PubMed
  14. Intern Med. 2011;50(4):339-43 - PubMed
  15. Diabetes Care. 2011 Sep;34(9):e146 - PubMed
  16. Pediatr Diabetes. 2012 Dec;13(8):652-5 - PubMed
  17. Clin Endocrinol (Oxf). 2014 Aug;81(2):204-9 - PubMed
  18. Endocrinol Metab (Seoul). 2013 Dec;28(4):326-30 - PubMed
  19. Can J Physiol Pharmacol. 2015 Dec;93(12):1021-7 - PubMed
  20. Clin Chem Lab Med. 2016 Nov 1;54(11):1715-1724 - PubMed
  21. Lancet. 1986 Dec 13;2(8520):1351-3 - PubMed
  22. Clin Chem Lab Med. 2018 May 24;56(6):889-895 - PubMed
  23. Tohoku J Exp Med. 1972 Jul;107(3):277-86 - PubMed
  24. J Exp Med. 1994 Sep 1;180(3):873-83 - PubMed
  25. Eur J Clin Chem Clin Biochem. 1997 May;35(5):365-7 - PubMed

Publication Types