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Martins T, Sponchiado M, Ojeda-Rojas OA, et al. Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle. J Anim Sci Biotechnol. 2018;9:87doi: 10.1186/s40104-018-0302-9.
Martins, T., Sponchiado, M., Ojeda-Rojas, O. A., Gonella-Diaza, A. M., Batista, E. O. S., Cardoso, B. O., Rocha, C. C., Basso, A. C., & Binelli, M. (2018). Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle. Journal of animal science and biotechnology, 987. https://doi.org/10.1186/s40104-018-0302-9
Martins, T, et al. "Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle." Journal of animal science and biotechnology vol. 9 (2018): 87. doi: https://doi.org/10.1186/s40104-018-0302-9
Martins T, Sponchiado M, Ojeda-Rojas OA, Gonella-Diaza AM, Batista EOS, Cardoso BO, Rocha CC, Basso AC, Binelli M. Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle. J Anim Sci Biotechnol. 2018 Dec 07;9:87. doi: 10.1186/s40104-018-0302-9. eCollection 2018. PMID: 30555692; PMCID: PMC6284308.
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J Anim Sci Biotechnol. 2018 Dec 07;9:87. doi: 10.1186/s40104-018-0302-9. eCollection 2018.

Exacerbated conceptus signaling does not favor establishment of pregnancy in beef cattle.

Journal of animal science and biotechnology

T Martins, M Sponchiado, O A Ojeda-Rojas, A M Gonella-Diaza, E O S Batista, B O Cardoso, C C Rocha, A C Basso, M Binelli

Affiliations

  1. 1Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, São Paulo, Brazil.
  2. 2Department of Nutrition and Animal Production, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, São Paulo, Brazil.
  3. In Vitro Brasil, Mogi Mirim, São Paulo, Brazil.
  4. 4Department of Animal Sciences, University of Florida, Gainesville, Florida, USA.

PMID: 30555692 PMCID: PMC6284308 DOI: 10.1186/s40104-018-0302-9

Abstract

BACKGROUND: Insufficient production of anti-luteolytic signals by the pre-attachment embryo is considered a major cause of pregnancy failure in cattle. We tested the hypothesis that transfer of multiple blastocysts (

RESULTS: On D5, iP4-treated cows had P4 concentrations 2.07-fold greater than non-iP4 treated (

CONCLUSIONS: A substantial proportion of cows had EEM (31%) and LEM (20%) even after transferring multiple blastocysts. This argues that mortality was due to poor uterine receptivity that could not be reversed by supplemental P4 or overcome by transferring multiple blastocysts. Further, a given uterine environment was not necessarily adequate to all embryos.

Keywords: Corpus luteum; Luteolysis, Pregnancy; Uterus

Conflict of interest statement

Not applicable.Animal procedures were approved by the Ethics and Animal Handling Committee of the University of São Paulo (CEUA-FMVZ/USP, n° 4,664,220,316). The experiments were conducted at the Unive

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