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Kobylinska L, Patereha I, Finiuk N, et al. Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier. Cancer Nanotechnol. 2018;9(1):11doi: 10.1186/s12645-018-0045-5.
Kobylinska, L., Patereha, I., Finiuk, N., Mitina, N., Riabtseva, A., Kotsyumbas, I., Stoika, R., Zaichenko, A., & Vari, S. G. (2018). Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier. Cancer nanotechnology, 9(1), 11. https://doi.org/10.1186/s12645-018-0045-5
Kobylinska, Lesya, et al. "Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier." Cancer nanotechnology vol. 9,1 (2018): 11. doi: https://doi.org/10.1186/s12645-018-0045-5
Kobylinska L, Patereha I, Finiuk N, Mitina N, Riabtseva A, Kotsyumbas I, Stoika R, Zaichenko A, Vari SG. Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier. Cancer Nanotechnol. 2018;9(1):11. doi: 10.1186/s12645-018-0045-5. Epub 2018 Dec 20. PMID: 30613308; PMCID: PMC6302051.
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Cancer Nanotechnol. 2018;9(1):11. doi: 10.1186/s12645-018-0045-5. Epub 2018 Dec 20.

Comb-like PEG-containing polymeric composition as low toxic drug nanocarrier.

Cancer nanotechnology

Lesya Kobylinska, Igor Patereha, Natalia Finiuk, Natalia Mitina, Anna Riabtseva, Igor Kotsyumbas, Rostyslav Stoika, Alexander Zaichenko, Sandor G Vari

Affiliations

  1. 1Danylo Halytsky Lviv National Medical University, Pekarska str., 69a, Lviv, 79010 Ukraine.
  2. State Scientific-Research Control Institute of Veterinary Medicinal Products and Feed Additives, Donetska str., 11, Lviv, 79019 Ukraine.
  3. 3Institute of Cell Biology, Drahomanov str., 14/16, Lviv, 79005 Ukraine.
  4. 4Lviv Polytechnic National University, S. Bandera str., 12, Lviv, 79013 Ukraine.
  5. 5International Research and Innovation in Medicine Program, Cedars-Sinai Medical Center, 6500 Wilshire Blvd., Ste. 2102, Los Angeles, CA 90048-5502 USA.

PMID: 30613308 PMCID: PMC6302051 DOI: 10.1186/s12645-018-0045-5

Abstract

BACKGROUND: Development of biocompatible multifunctional polymeric drug carriers is crucial in modern pharmaceutics aimed to create "smart" drugs. The high potential of the PEGylated comb-like polymeric nanocarrier (PNC) in delivering both traditional and experimental drugs to tumor cells in vitro and in vivo has been demonstrated previously. In the present study, we investigated the general toxicity of polyethylene glycol (PEG) processed with both covalent and non-covalent attachments of PEG to compose a comb-like polymer that behaves like a simple chain of n monomers decorated with swollen side chains. The PNC possesses properties of a water-soluble surfactant containing methyl-terminated PEG side branches in some monomer units attached covalently to the carbon chain backbone.

RESULTS: We have demonstrated that the synthesized PNC possesses weak toxic effects toward human leukemia cells (HL-60 and Jurkat lines), as well as toward hepatocellular (HepG2), colon (HCT116) and breast (MCF-7) tumor cell lines. Additionally, after a long period (20 days) of intraperitoneal administration, the PNC had no significant toxic effects in laboratory white mice (470 mg/kg body mass in 1 ml) and Wistar rats (440 mg/kg body mass in 10 ml).

CONCLUSION: The developed PNC we studied can be qualified as a compound of grade 4 toxicity (low toxicity substance). The reduced toxicity of this PNC in combination with its improved bioavailability and previously detected capability to enhance cytotoxicity toward tumor cells in vitro and potential tumor treatment effects in vivo suggests its potential as a safe drug delivery platform for treating various diseases, especially cancer.

Keywords: Drug delivery system; Mice; Polyethylene glycol; Polymeric nanocarrier; Rats; Toxicity

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