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van Veen DE, Verhelst CC, van Dellen RT, et al. Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone. J Pain Res. 2018;11:3205-3210doi: 10.2147/JPR.S185197.
van Veen, D. E., Verhelst, C. C., van Dellen, R. T., & Koopman, J. (2018). Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone. Journal of pain research, 113205-3210. https://doi.org/10.2147/JPR.S185197
van Veen, David E, et al. "Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone." Journal of pain research vol. 11 (2018): 3205-3210. doi: https://doi.org/10.2147/JPR.S185197
van Veen DE, Verhelst CC, van Dellen RT, Koopman J. Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone. J Pain Res. 2018 Dec 14;11:3205-3210. doi: 10.2147/JPR.S185197. eCollection 2018. PMID: 30588072; PMCID: PMC6299470.
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J Pain Res. 2018 Dec 14;11:3205-3210. doi: 10.2147/JPR.S185197. eCollection 2018.

Sublingual sufentanil (Zalviso) patient-controlled analgesia after total knee arthroplasty: a retrospective comparison with oxycodone with or without dexamethasone.

Journal of pain research

David E van Veen, Christiaan Cwm Verhelst, Roelof T van Dellen, Jsha Koopman

Affiliations

  1. Erasmus University Rotterdam, Rotterdam, The Netherlands, [email protected].
  2. Department of Orthopedic Surgery, Maasstad Hospital, Rotterdam, The Netherlands.
  3. Department of Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands.
  4. Department of Anesthesiology, Maasstad Hospital, Rotterdam, The Netherlands.

PMID: 30588072 PMCID: PMC6299470 DOI: 10.2147/JPR.S185197

Abstract

Postoperative pain is a major problem, especially in orthopedic surgery. Our data suggest suboptimal pain management after total knee arthroplasty. This study evaluated a sufentanil sublingual tablet system (Zalviso) to optimize postoperative pain treatment. This retrospective, single-center, cohort study was conducted between January 2017 and September 2017. Zalviso as standard treatment was compared with a cohort receiving oxycodone (Oxy) immediate release and Oxy extended release and another receiving Oxy immediate release, Oxy extended release, and dexamethasone (Dexa + Oxy). The primary end point, pain intensity, was assessed on a numeric rating scale (NRS). Highest, lowest, and number of NRS scores >7 were collected. Secondary end points included length of hospital stay, nausea, and mobilization on the day of surgery. Patients receiving Dexa + Oxy had a lower lowest-pain intensity on day 0 (median 0, IQR 0-0) when compared to patients receiving Oxy (median 2, IQR 0-3;

Keywords: Zalviso; acute pain; multimodal treatment; opioid; postoperative pain; sublingual formulation; sublingual sufentanil tablet system; sufentanil; total knee arthroplasty

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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