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El-Heis S, Crozier SR, Healy E, et al. Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study. Clin Epidemiol. 2018;10:1851-1864doi: 10.2147/CLEP.S175878.
El-Heis, S., Crozier, S. R., Healy, E., Robinson, S. M., Harvey, N. C., Cooper, C., Inskip, H. M., Baird, J., Godfrey, K. M. (2018). Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study. Clinical epidemiology, 101851-1864. https://doi.org/10.2147/CLEP.S175878
El-Heis, Sarah, et al. "Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study." Clinical epidemiology vol. 10 (2018): 1851-1864. doi: https://doi.org/10.2147/CLEP.S175878
El-Heis S, Crozier SR, Healy E, Robinson SM, Harvey NC, Cooper C, Inskip HM, Baird J, Godfrey KM. Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study. Clin Epidemiol. 2018 Dec 12;10:1851-1864. doi: 10.2147/CLEP.S175878. eCollection 2018. PMID: 30588116; PMCID: PMC6296686.
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Clin Epidemiol. 2018 Dec 12;10:1851-1864. doi: 10.2147/CLEP.S175878. eCollection 2018.

Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study.

Clinical epidemiology

Sarah El-Heis, Sarah R Crozier, Eugene Healy, Sian M Robinson, Nicholas C Harvey, Cyrus Cooper, Hazel M Inskip, Janis Baird, Keith M Godfrey,

Affiliations

  1. Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK, [email protected].
  2. Dermatopharmacology, Faculty of Medicine, University of Southampton, Southampton, UK.
  3. NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK, [email protected].
  4. NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK.
  5. Institute of Developmental Sciences, University of Southampton, Southampton, UK, [email protected].

PMID: 30588116 PMCID: PMC6296686 DOI: 10.2147/CLEP.S175878

Abstract

BACKGROUND: Infants with atopic eczema have an increased risk of impaired growth, but the origin of this impairment is unclear. The aim of this study was to examine fetal and infant growth in relation to infantile atopic eczema.

METHODS: Within the UK Southampton Women's Survey, 1,759 infants with known maternal menstrual data had anthropometric measurements at 11, 19, and 34 weeks' gestation, birth, and ages 6 and 12 months, enabling derivation of growth velocity SD scores. Infantile atopic eczema at ages 6 and/or 12 months was ascertained using modified UK Working Party diagnostic criteria.

RESULTS: Expressed per SD increase, higher femur length and abdominal circumference at 34 weeks' gestation were associated with decreased risks of atopic eczema (eczema OR/SD increase 0.81 [95% CI 0.69-0.96],

CONCLUSION: Infants with atopic eczema demonstrate altered patterns of fetal growth, including faltering of linear growth in utero, prior to the clinical onset of atopic eczema. These findings suggest growth falters prior to the start of clinical atopic eczema and its treatment.

Keywords: atopic eczema; fetal growth; infant growth

Conflict of interest statement

Disclosure KMG has received reimbursement for speaking at conferences sponsored by companies selling nutritional products and is part of an academic consortium that has received research funding from

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