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Hamon M, Geindreau D, Guittet L, et al. Additional diagnostic value of new CT imaging techniques for the functional assessment of coronary artery disease: a meta-analysis. Eur Radiol. 2019;29(6):3044-3061doi: 10.1007/s00330-018-5919-8.
Hamon, M., Geindreau, D., Guittet, L., Bauters, C., & Hamon, M. (2019). Additional diagnostic value of new CT imaging techniques for the functional assessment of coronary artery disease: a meta-analysis. European radiology, 29(6), 3044-3061. https://doi.org/10.1007/s00330-018-5919-8
Hamon, Michèle, et al. "Additional diagnostic value of new CT imaging techniques for the functional assessment of coronary artery disease: a meta-analysis." European radiology vol. 29,6 (2019): 3044-3061. doi: https://doi.org/10.1007/s00330-018-5919-8
Hamon M, Geindreau D, Guittet L, Bauters C, Hamon M. Additional diagnostic value of new CT imaging techniques for the functional assessment of coronary artery disease: a meta-analysis. Eur Radiol. 2019 Jun;29(6):3044-3061. doi: 10.1007/s00330-018-5919-8. Epub 2019 Jan 07. PMID: 30617482.
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Eur Radiol. 2019 Jun;29(6):3044-3061. doi: 10.1007/s00330-018-5919-8. Epub 2019 Jan 07.

Additional diagnostic value of new CT imaging techniques for the functional assessment of coronary artery disease: a meta-analysis.

European radiology

Michèle Hamon, Damien Geindreau, Lydia Guittet, Christophe Bauters, Martial Hamon

Affiliations

  1. Departement de Radiologie, Centre Hospitalier Universitaire de Caen, Avenue Côte de Nacre, 14033, Caen, Normandie, France. [email protected].
  2. Université de Caen, UFR de Médecine, Caen, Normandie, France. [email protected].
  3. Departement de Radiologie, Centre Hospitalier Universitaire de Caen, Avenue Côte de Nacre, 14033, Caen, Normandie, France.
  4. Université de Caen, UFR de Médecine, Caen, Normandie, France.
  5. Departement d'Information Médicale, Centre Hospitalier Universitaire de Caen, Caen, Normandie, France.
  6. Departement de Cardiologie, Centre Hospitalier Universitaire Regional de Lille, Lille, Hauts de France, France.
  7. INSERM U1167, Université de Lille, UFR de Médecine, Lille, Hauts de France, France.

PMID: 30617482 DOI: 10.1007/s00330-018-5919-8

Abstract

OBJECTIVES: To determine the diagnostic performance of cardiac computed tomography (CT)-based modalities including coronary CT angiography (CTA), stress myocardial CT perfusion (stress CTP), computer simulation of fractional flow reserve by CT (FFR

METHODS: PubMed and Cochrane databases were searched for original articles until July 2018. Diagnostic accuracy results were pooled at per-patient and per-vessel level using random effect models.

RESULTS: Fifty articles were included in the meta-analysis (3024 subjects). The per-patient analysis per imaging modality demonstrated a pooled positive likelihood ratio (PLR) of 1.78 (95% confidence interval CI 1.49-2.11), 4.58 (95% CI 3.54-5.91), and 3.45 (95% CI 2.38-5.00) for CTA, stress CTP, and FFR

CONCLUSION: With improved PLR and specificity, stress CTP and FFR

KEY POINTS: • New functional CT imaging techniques, such as stress CTP and FFR

Keywords: Computed tomography angiography; Coronary angiography; Coronary artery disease; Myocardial fractional flow reserve; Myocardial perfusion imaging

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