Display options
Cite
Magnard R, Vachez Y, Carcenac C, et al. Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease. Front Behav Neurosci. 2018;12:312doi: 10.3389/fnbeh.2018.00312.
Magnard, R., Vachez, Y., Carcenac, C., Boulet, S., Houeto, J. L., Savasta, M., Belin, D., & Carnicella, S. (2018). Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease. Frontiers in behavioral neuroscience, 12312. https://doi.org/10.3389/fnbeh.2018.00312
Magnard, Robin, et al. "Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease." Frontiers in behavioral neuroscience vol. 12 (2018): 312. doi: https://doi.org/10.3389/fnbeh.2018.00312
Magnard R, Vachez Y, Carcenac C, Boulet S, Houeto JL, Savasta M, Belin D, Carnicella S. Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease. Front Behav Neurosci. 2018 Dec 13;12:312. doi: 10.3389/fnbeh.2018.00312. eCollection 2018. PMID: 30618665; PMCID: PMC6300586.
Copy Download .nbib Format: NLM
Share it on

Front Behav Neurosci. 2018 Dec 13;12:312. doi: 10.3389/fnbeh.2018.00312. eCollection 2018.

Nigrostriatal Dopaminergic Denervation Does Not Promote Impulsive Choice in the Rat: Implication for Impulse Control Disorders in Parkinson's Disease.

Frontiers in behavioral neuroscience

Robin Magnard, Yvan Vachez, Carole Carcenac, Sabrina Boulet, Jean-Luc Houeto, Marc Savasta, David Belin, Sebastien Carnicella

Affiliations

  1. INSERM U1216 and Univ. Grenoble Alpes, Grenoble Institut des Neurosciences (GIN), Grenoble, France.
  2. CIC-INSERM 1402, Service de Neurologie, CHU de Poitiers, Université de Poitiers, Poitiers, France.
  3. Department of Psychology, Faculty of Biology, University of Cambridge, Cambridge, United Kingdom.

PMID: 30618665 PMCID: PMC6300586 DOI: 10.3389/fnbeh.2018.00312

Abstract

Impulse control disorders (ICDs) are frequent behavioral complications of dopaminergic (DA) replacement therapies (DRTs) in Parkinson's disease (PD). Impulsive choice, which refers to an inability to tolerate delays to reinforcement, has been identified as a core pathophysiological process of ICDs. Although impulsive choices are exacerbated in PD patients with ICDs under DRTs, some clinical and preclinical studies suggest that the DA denervation of the dorsal striatum induced by the neurodegenerative process as well as a pre-existing high impulsivity trait, may both contribute to the emergence of ICDs in PD. We therefore investigated in a preclinical model in rats, specifically designed to study PD-related non-motor symptoms, the effect of nigrostriatal DA denervation on impulsive choice, in relation to pre-existing levels of impulsivity, measured in a Delay Discounting Task (DDT). In this procedure, rats had the choice between responding for a small sucrose reinforcer delivered immediately, or a larger sucrose reinforcer, delivered after a 0, 5, 10 or 15 s delay. In two different versions of the task, the preference for the large reinforcer decreased as the delay increased. However, and in contrast to our initial hypothesis, this discounting effect was neither exacerbated by, or related to, the extent of the substantia nigra pars compacta (SNc) DA lesion, nor it was influenced by pre-existing variability in impulsive choice. These results therefore question the potential implication of the nigrostriatal DA system in impulsive choice, as well as the DA neurodegenerative process as a factor contributing significantly to the development of ICDs in PD.

Keywords: 6-OHDA; Parkinson’s disease; delay discounting task; dopaminergic nigrostriatal system; impulse control disorders; impulsive choice; rats

References

  1. J Exp Anal Behav. 2001 Sep;76(2):235-43 - PubMed
  2. Curr Opin Neurol. 2003 Dec;16 Suppl 2:S3-9 - PubMed
  3. Lancet. 2004 May 29;363(9423):1783-93 - PubMed
  4. Curr Protoc Neurosci. 2007 Apr;Chapter 8:Unit 8.22 - PubMed
  5. Science. 2008 Jun 6;320(5881):1352-5 - PubMed
  6. Neuron. 2009 Feb 26;61(4):502-10 - PubMed
  7. Lancet Neurol. 2009 Dec;8(12):1140-9 - PubMed
  8. Arch Neurol. 2010 May;67(5):589-95 - PubMed
  9. Prog Neurobiol. 2010 Dec;92(4):533-57 - PubMed
  10. Brain Res Bull. 2012 Jun 1;88(2-3):251-60 - PubMed
  11. Mov Disord. 2011 Sep;26(11):2004-10 - PubMed
  12. Front Syst Neurosci. 2011 May 18;5:31 - PubMed
  13. Curr Opin Neurol. 2011 Aug;24(4):324-30 - PubMed
  14. Front Psychol. 2011 Jul 14;2:163 - PubMed
  15. Nat Rev Neurol. 2011 Sep 13;7(10):541-2 - PubMed
  16. J Exp Anal Behav. 2011 Nov;96(3):427-39 - PubMed
  17. Parkinsonism Relat Disord. 2012 Jan;18 Suppl 1:S104-6 - PubMed
  18. Neuropsychopharmacology. 2012 May;37(6):1397-408 - PubMed
  19. Neuropsychopharmacology. 2012 May;37(6):1377-86 - PubMed
  20. Neuroscience. 2012 Jul 26;215:42-58 - PubMed
  21. Mol Psychiatry. 2014 Mar;19(3):358-67 - PubMed
  22. J Neuropsychol. 2013 Sep;7(2):255-83 - PubMed
  23. Biol Psychiatry. 2014 May 15;75(10):825-32 - PubMed
  24. Mov Disord. 2014 Jun;29(7):912-20 - PubMed
  25. Brain. 2014 Apr;137(Pt 4):1145-55 - PubMed
  26. Brain. 2014 Jul;137(Pt 7):1986-97 - PubMed
  27. Transl Psychiatry. 2014 Jun 17;4:e401 - PubMed
  28. J Parkinsons Dis. 2015;5(3):625-36 - PubMed
  29. PLoS One. 2015 Apr 30;10(4):e0122063 - PubMed
  30. Neurobiol Dis. 2015 Oct;82:561-573 - PubMed
  31. Parkinsonism Relat Disord. 2015 Nov;21(11):1330-5 - PubMed
  32. Neurobiol Learn Mem. 2016 Jan;127:17-26 - PubMed
  33. Nat Commun. 2015 Dec 14;6:10088 - PubMed
  34. Transl Psychiatry. 2016 Mar 08;6:e753 - PubMed
  35. Neuropharmacology. 2016 Oct;109:69-77 - PubMed
  36. Front Psychiatry. 2016 May 30;7:91 - PubMed
  37. Brain. 2016 Sep;139(Pt 9):2486-502 - PubMed
  38. Sci Rep. 2017 Jan 30;7:41589 - PubMed
  39. Nat Rev Neurosci. 2017 Feb 17;18(3):158-171 - PubMed
  40. Front Behav Neurosci. 2017 Aug 08;11:145 - PubMed
  41. Psychopharmacology (Berl). 1996 Nov;128(2):161-70 - PubMed

Publication Types

Grant support