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Zou XP, Jiang YY, Liao Y, et al. The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature. Onco Targets Ther. 2019;12:953-958doi: 10.2147/OTT.S186102.
Zou, X. P., Jiang, Y. Y., Liao, Y., Dang, Y. W., Chen, G., Feng, Z. B., & Ma, Y. (2019). The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature. OncoTargets and therapy, 12953-958. https://doi.org/10.2147/OTT.S186102
Zou, Xiao-Ping, et al. "The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature." OncoTargets and therapy vol. 12 (2019): 953-958. doi: https://doi.org/10.2147/OTT.S186102
Zou XP, Jiang YY, Liao Y, Dang YW, Chen G, Feng ZB, Ma Y. The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature. Onco Targets Ther. 2019 Jan 30;12:953-958. doi: 10.2147/OTT.S186102. eCollection 2019. PMID: 30774381; PMCID: PMC6361228.
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Onco Targets Ther. 2019 Jan 30;12:953-958. doi: 10.2147/OTT.S186102. eCollection 2019.

The coexistence of a Wilms' tumor and renal cell carcinoma in children: a case report and review of the literature.

OncoTargets and therapy

Xiao-Ping Zou, Yao-Ying Jiang, Yan Liao, Yi-Wu Dang, Gang Chen, Zhen-Bo Feng, Yun Ma

Affiliations

  1. Department of Pathology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China, [email protected].
  2. Department of Pathology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.

PMID: 30774381 PMCID: PMC6361228 DOI: 10.2147/OTT.S186102

Abstract

A combination of a Wilms' tumor (WT) and renal cell carcinoma (RCC) is an extremely rare pediatric renal neoplasm. Its prognosis and clinicopathological features remain unclarified. Herein, we describe a case of the coexistence of a WT and an RCC in a male child aged 5 years and 10 months. The child had symptoms of hematuria for more than 1 month. Although his irises were clear, medical imaging revealed a potential malignant tumor in the left kidney. The patient underwent resection of the left kidney. The pathological diagnosis was the coexistence of a WT and papillary RCC. Negative surgical margins were examined. One month following the resection, chemotherapy with vincristine plus dactinomycin (EE-4A regimen) was commenced. At the 69-month follow-up, there was no recurrence or metastasis. The coexistence of a WT and an RCC in the pediatric population is considered a rare pathological event. At present, there is no standard treatment for these renal neoplasms. In this study, the RCC treatment, which was the same as that applied in cases of WTs, was reasonable.

Keywords: coexistence; nephroblastoma; papillary renal cell carcinoma; renal cell carcinoma

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

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