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Yaribeygi H, Atkin SL, Sahebkar A. Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes. J Cell Biochem. 2019;doi: 10.1002/jcb.28467.
Yaribeygi, H., Atkin, S. L., & Sahebkar, A. (2019). Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes. Journal of cellular biochemistry, . https://doi.org/10.1002/jcb.28467
Yaribeygi, Habib, et al. "Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes." Journal of cellular biochemistry vol. (2019). doi: https://doi.org/10.1002/jcb.28467
Yaribeygi H, Atkin SL, Sahebkar A. Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes. J Cell Biochem. 2019 Feb 18; doi: 10.1002/jcb.28467. Epub 2019 Feb 18. PMID: 30775811.
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J Cell Biochem. 2019 Feb 18; doi: 10.1002/jcb.28467. Epub 2019 Feb 18.

Natural compounds with DPP-4 inhibitory effects: Implications for the treatment of diabetes.

Journal of cellular biochemistry

Habib Yaribeygi, Stephen L Atkin, Amirhossein Sahebkar

Affiliations

  1. Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  2. Weill Cornell Medicine Qatar, Doha, Qatar.
  3. Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  4. Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
  5. School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 30775811 DOI: 10.1002/jcb.28467

Abstract

Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetes agents that decrease blood glucose by preventing the degradation of endogenous glucagon-like peptide-1. The first DPP-4 was sitagliptin followed by several other agents in the class introduced to manage diabetes. Recent studies have suggested that naturally occurring compounds can exert an antidiabetes effect through DPP-4 inhibition. Such compounds may have a place in the treatment of diabetes within the diet; however, while DPP-4 inhibition alone is not associated with hypoglycemia, in combinations with other medication hypoglycemia can result, therefore, it is critical to know what herbal or food-based compounds may have these activities in the management of diabetes patients. In this review, we have outlined the compounds that have DPP-4 inhibition that may have utility in the treatment of diabetes.

© 2019 Wiley Periodicals, Inc.

Keywords: alkaloids; diabetes mellitus; dipeptidyl peptidase-4 inhibitors; glycosides; herbal compounds; phenol

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