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Clin Case Rep. 2018 Nov 28;7(1):164-169. doi: 10.1002/ccr3.1924. eCollection 2019 Jan.

A rare case of hepatosplenic gamma-delta T-cell lymphoma and secondary hemophagocytic lymphohistiocytosis.

Clinical case reports

Philip H Brandt, Leena T Rahmat, Syed S Ali

Affiliations

  1. Department of Hematology and Oncology, D'Amour Center for Cancer Care, Baystate Medical Center University of Massachusetts Springfield Massachusetts.
  2. Department of Oncology Johns Hopkins University, Sidney Kimmel Comprehensive Cancer Center, Sibley Memorial Hospital Washington District of Columbia.

PMID: 30656034 PMCID: PMC6333078 DOI: 10.1002/ccr3.1924

Abstract

Hepatosplenic gamma-delta T-cell lymphoma with concurrent hemophogocytic lymphohistiocytosis is a rare but well-recognized clinical scenario, associated with a grim prognosis. Clinicians must be aware of this aggressive type of lymphoma so that a prompt diagnosis can be made with timely initiation of systemic therapy and referral for bone marrow transplant.

Keywords: hemophagocytic lymphohistiocytosis; hepatosplenic T‐cell lymphoma

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