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Yhoshu E, Lone YA, Mahajan JK, et al. Hepatoblastoma with Precocious Puberty. J Indian Assoc Pediatr Surg. 2019;24(1):68-71doi: 10.4103/jiaps.JIAPS_102_18.
Yhoshu, E., Lone, Y. A., Mahajan, J. K., & Singh, U. B. (2019). Hepatoblastoma with Precocious Puberty. Journal of Indian Association of Pediatric Surgeons, 24(1), 68-71. https://doi.org/10.4103/jiaps.JIAPS_102_18
Yhoshu, Enono, et al. "Hepatoblastoma with Precocious Puberty." Journal of Indian Association of Pediatric Surgeons vol. 24,1 (2019): 68-71. doi: https://doi.org/10.4103/jiaps.JIAPS_102_18
Yhoshu E, Lone YA, Mahajan JK, Singh UB. Hepatoblastoma with Precocious Puberty. J Indian Assoc Pediatr Surg. 2019 Jan-Mar;24(1):68-71. doi: 10.4103/jiaps.JIAPS_102_18. PMID: 30686892; PMCID: PMC6322182.
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J Indian Assoc Pediatr Surg. 2019 Jan-Mar;24(1):68-71. doi: 10.4103/jiaps.JIAPS_102_18.

Hepatoblastoma with Precocious Puberty.

Journal of Indian Association of Pediatric Surgeons

Enono Yhoshu, Yasir A Lone, Jai K Mahajan, Umesh Bahadur Singh

Affiliations

  1. Department of Pediatric Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

PMID: 30686892 PMCID: PMC6322182 DOI: 10.4103/jiaps.JIAPS_102_18

Abstract

Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.

Keywords: Hepatoblastoma; precocious; puberty; virilization

Conflict of interest statement

There are no conflicts of interest.

References

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