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Risius OJ, Onur OA, Dronse J, et al. Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval. Front Hum Neurosci. 2019;12:528doi: 10.3389/fnhum.2018.00528.
Risius, O. J., Onur, O. A., Dronse, J., von Reutern, B., Richter, N., Fink, G. R., & Kukolja, J. (2018). Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval. Frontiers in human neuroscience, 12528. https://doi.org/10.3389/fnhum.2018.00528
Risius, Okka J, et al. "Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval." Frontiers in human neuroscience vol. 12 (2018): 528. doi: https://doi.org/10.3389/fnhum.2018.00528
Risius OJ, Onur OA, Dronse J, von Reutern B, Richter N, Fink GR, Kukolja J. Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval. Front Hum Neurosci. 2019 Jan 09;12:528. doi: 10.3389/fnhum.2018.00528. eCollection 2018. PMID: 30687046; PMCID: PMC6333856.
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Front Hum Neurosci. 2019 Jan 09;12:528. doi: 10.3389/fnhum.2018.00528. eCollection 2018.

Neural Network Connectivity During Post-encoding Rest: Linking Episodic Memory Encoding and Retrieval.

Frontiers in human neuroscience

Okka J Risius, Oezguer A Onur, Julian Dronse, Boris von Reutern, Nils Richter, Gereon R Fink, Juraj Kukolja

Affiliations

  1. Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany.
  2. Department of Neurology, University Hospital Cologne, Cologne, Germany.
  3. Department of Neurology and Neurophysiology, Helios University Hospital Wuppertal, Wuppertal, Germany.

PMID: 30687046 PMCID: PMC6333856 DOI: 10.3389/fnhum.2018.00528

Abstract

Commonly, a switch between networks mediating memory encoding and those mediating retrieval is observed. This may not only be due to differential involvement of neural resources due to distinct cognitive processes but could also reflect the formation of new memory traces and their dynamic change during consolidation. We used resting state fMRI to measure functional connectivity (FC) changes during post-encoding rest, hypothesizing that during this phase, new functional connections between encoding- and retrieval-related regions are created. Interfering and reminding tasks served as experimental modulators to corroborate that the observed FC differences indeed reflect changes specific to post-encoding rest. The right inferior occipital and fusiform gyri (active during encoding) showed increased FC with the left inferior frontal gyrus and the left middle temporal gyrus (MTG) during post-encoding rest. Importantly, the left MTG subsequently also mediated successful retrieval. This finding might reflect the formation of functional connections between encoding- and retrieval-related regions during undisturbed post-encoding rest. These connections were vulnerable to experimental modulation: Cognitive interference disrupted FC changes during post-encoding rest resulting in poorer memory performance. The presentation of reminders also inhibited FC increases but without affecting memory performance. Our results contribute to a better understanding of the mechanisms by which post-encoding rest bridges the gap between encoding- and retrieval-related networks.

Keywords: episodic memory consolidation; functional connectivity; memory interference; memory trace; resting state fMRI

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