Display options
Cite
Kim K, Do HJ, Oh TW, et al. Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang. Front Pharmacol. 2019;9:1502doi: 10.3389/fphar.2018.01502.
Kim, K., Do, H. J., Oh, T. W., Kim, K. Y., Kim, T. H., Ma, J. Y., & Park, K. I. (2018). Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang. Frontiers in pharmacology, 91502. https://doi.org/10.3389/fphar.2018.01502
Kim, Kyungho, et al. "Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang." Frontiers in pharmacology vol. 9 (2018): 1502. doi: https://doi.org/10.3389/fphar.2018.01502
Kim K, Do HJ, Oh TW, Kim KY, Kim TH, Ma JY, Park KI. Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang. Front Pharmacol. 2019 Jan 09;9:1502. doi: 10.3389/fphar.2018.01502. eCollection 2018. PMID: 30687085; PMCID: PMC6333754.
Copy Download .nbib Format: NLM
Share it on

Front Pharmacol. 2019 Jan 09;9:1502. doi: 10.3389/fphar.2018.01502. eCollection 2018.

Antiplatelet and Antithrombotic Activity of a Traditional Medicine, Hwangryunhaedok-Tang.

Frontiers in pharmacology

Kyungho Kim, Hyun Ju Do, Tae Woo Oh, Kwang-Youn Kim, Tae Hoon Kim, Jin Yel Ma, Kwang-Il Park

Affiliations

  1. Korean Medicine-Application Center, Korea Institute of Oriental Medicine, Daegu, South Korea.
  2. Department of Food Science and Biotechnology, Daegu University, Gyeongsan, South Korea.

PMID: 30687085 PMCID: PMC6333754 DOI: 10.3389/fphar.2018.01502

Abstract

Platelet activation and accumulation at the site of vascular injury are central to thrombus formation resulted in thrombotic disorders. Medicinal herbs could be one of the most important pharmaceutical agents that ameliorate thrombotic disorders, such as unstable angina, myocardial infarction, stroke, and peripheral vascular diseases. Hwangryunhaedok-tang (HRT) is a traditional herbal medicine that displays multiple biological properties including anti-inflammatory abilities. However, its role in platelet activation has not been fully studied. Hence, we examined whether HRT has a potent inhibitory effect on platelet aggregation and thrombus formation. We demonstrated that HRT (30, 50, and 100 μg/ml) significantly impaired thrombin- and collagen-related peptide-induced platelet aggregation, granule secretion, thromboxane B

Keywords: Hwangryunhaedok-tang (Hwanglianjiedu-tang); hemostasis; platelet; platelet aggregation and activation; thrombosis

References

  1. J Nutr. 2000 Jan;130(1):53-6 - PubMed
  2. J Ethnopharmacol. 2000 Dec;73(3):405-13 - PubMed
  3. Annu Rev Biochem. 2001;70:281-312 - PubMed
  4. Planta Med. 2001 Dec;67(9):807-10 - PubMed
  5. J Biol Chem. 2002 Oct 18;277(42):39493-8 - PubMed
  6. Thromb Res. 2002 May 15;106(4-5):223-7 - PubMed
  7. J Thromb Haemost. 2003 Aug;1(8):1820-8 - PubMed
  8. Jpn J Pharmacol. 1992 Jun;59(2):159-69 - PubMed
  9. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2009 Jan;38(1):75-80 - PubMed
  10. J Thromb Haemost. 2009 Jul;7(7):1057-66 - PubMed
  11. J Pharm Pharmacol. 2009 Dec;61(12):1699-707 - PubMed
  12. Thromb Res. 1990 Nov 15;60(4):269-80 - PubMed
  13. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2341-9 - PubMed
  14. Mini Rev Med Chem. 2011 Feb;11(2):131-42 - PubMed
  15. J Ethnopharmacol. 2011 May 17;135(2):561-8 - PubMed
  16. Front Biosci (Landmark Ed). 2011 Jun 01;16:2144-60 - PubMed
  17. Chest. 2012 Feb;141(2 Suppl):e89S-e119S - PubMed
  18. J Biol Chem. 2012 Nov 30;287(49):41277-87 - PubMed
  19. J Ethnopharmacol. 2013 Jan 30;145(2):465-75 - PubMed
  20. N Engl J Med. 1990 May 31;322(22):1549-54 - PubMed
  21. Evid Based Complement Alternat Med. 2013;2013:439690 - PubMed
  22. Phytomedicine. 2013 Jul 15;20(10):767-74 - PubMed
  23. Blood. 2013 Aug 8;122(6):1052-61 - PubMed
  24. Thromb Haemost. 2013 Nov;110(5):925-30 - PubMed
  25. Regul Toxicol Pharmacol. 2014 Apr;68(3):378-86 - PubMed
  26. Arch Pharm Res. 2015;38(5):893-903 - PubMed
  27. Fitoterapia. 2014 Oct;98:27-35 - PubMed
  28. Chin J Nat Med. 2015 Jan;13(1):30-40 - PubMed
  29. Biochem Pharmacol. 2015 Apr 1;94(3):186-94 - PubMed
  30. J Biosci Bioeng. 2015 Aug;120(2):181-6 - PubMed
  31. Pharmacogn Mag. 2015 Jul-Sep;11(43):562-6 - PubMed
  32. Blood. 2015 Oct 15;126(16):1952-64 - PubMed
  33. J Thromb Haemost. 2016 May;14(5):918-30 - PubMed
  34. Molecules. 2016 Apr 29;21(5): - PubMed
  35. Blood. 2017 Jan 12;129(2):209-225 - PubMed
  36. Physiology (Bethesda). 2017 Mar;32(2):162-177 - PubMed
  37. Sci Rep. 2017 Mar 09;7:44040 - PubMed
  38. Chest. 1986 Feb;89(2 Suppl):75S-81S - PubMed
  39. J Biol Chem. 1987 Apr 25;262(12):5592-5 - PubMed
  40. Br Heart J. 1985 Apr;53(4):363-73 - PubMed
  41. Cor Vasa. 1972;20(2):135-41 - PubMed
  42. Biochem Pharmacol. 1984 May 1;33(9):1525-30 - PubMed
  43. Blood. 1996 Sep 1;88(5):1684-91 - PubMed
  44. Thromb Haemost. 1996 Jun;75(6):945-9 - PubMed
  45. Inflammation. 1997 Jun;21(3):347-56 - PubMed
  46. Am J Clin Nutr. 1998 Feb;67(2):255-62 - PubMed

Publication Types