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Nanomaterials (Basel). 2019 Feb 18;9(2). doi: 10.3390/nano9020287.

Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment.

Nanomaterials (Basel, Switzerland)

Fadoua Sallem, Rihab Haji, Dominique Vervandier-Fasseur, Thomas Nury, Lionel Maurizi, Julien Boudon, Gérard Lizard, Nadine Millot

Affiliations

  1. Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), UMR 6303 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].
  2. Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].
  3. Institut de Chimie Moléculaire de l'Université de Bourgogne (ICMUB), UMR 6302 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].
  4. Laboratoire Bio-PeroxIL, EA7270, Université de Bourgogne Franche-Comté/Inserm, 21000 Dijon, France. [email protected].
  5. Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), UMR 6303 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].
  6. Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), UMR 6303 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].
  7. Laboratoire Bio-PeroxIL, EA7270, Université de Bourgogne Franche-Comté/Inserm, 21000 Dijon, France. [email protected].
  8. Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), UMR 6303 CNRS/Université Bourgogne Franche-Comté, 21000 Dijon, France. [email protected].

PMID: 30781702 PMCID: PMC6409721 DOI: 10.3390/nano9020287

Abstract

In this work, new nanohybrids based on superparamagnetic iron oxide nanoparticles (SPIONs) were elaborated and discussed for the first time as nanovectors of a derivative molecule of trans-resveratrol (RSV), a natural antioxidant molecule, which can be useful for brain disease treatment. The derivative molecule was chemically synthesized (4'-hydroxy-4-(3-aminopropoxy) trans-stilbene: HAPtS) and then grafted onto SPIONs surface using an organosilane coupling agent, which is 3-chloropropyltriethoxysilane (CPTES) and based on nucleophilic substitution reactions. The amount of HAPtS loaded onto SPIONs surface was estimated by thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS) analyses at 116 µmol·g

Keywords: drug delivery; glioma; iron oxide superparamagnetic nanoparticles; trans-resveratrol derivative

Conflict of interest statement

The authors declare no conflict of interest.

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