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Jeong GH, Lee KH, Lee IR, et al. Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis. J Clin Med. 2019;8(2)doi: 10.3390/jcm8020143.
Jeong, G. H., Lee, K. H., Lee, I. R., Oh, J. H., Kim, D. W., Shin, J. W., Kronbichler, A., Eisenhut, M., van der Vliet, H. J., Abdel-Rahman, O., Stubbs, B., Solmi, M., Veronese, N., Dragioti, E., Koyanagi, A., Radua, J., & Shin, J. I. (2019). Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis. Journal of clinical medicine, 8(2), . https://doi.org/10.3390/jcm8020143
Jeong, Gwang Hun, et al. "Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis." Journal of clinical medicine vol. 8,2 (2019). doi: https://doi.org/10.3390/jcm8020143
Jeong GH, Lee KH, Lee IR, Oh JH, Kim DW, Shin JW, Kronbichler A, Eisenhut M, van der Vliet HJ, Abdel-Rahman O, Stubbs B, Solmi M, Veronese N, Dragioti E, Koyanagi A, Radua J, Shin JI. Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis. J Clin Med. 2019 Jan 26;8(2). doi: 10.3390/jcm8020143. PMID: 30691103; PMCID: PMC6406478.
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J Clin Med. 2019 Jan 26;8(2). doi: 10.3390/jcm8020143.

Incidence of Capillary Leak Syndrome as an Adverse Effect of Drugs in Cancer Patients: A Systematic Review and Meta-Analysis.

Journal of clinical medicine

Gwang Hun Jeong, Keum Hwa Lee, I Re Lee, Ji Hyun Oh, Dong Wook Kim, Jae Won Shin, Andreas Kronbichler, Michael Eisenhut, Hans J van der Vliet, Omar Abdel-Rahman, Brendon Stubbs, Marco Solmi, Nicola Veronese, Elena Dragioti, Ai Koyanagi, Joaquim Radua, Jae Il Shin

Affiliations

  1. College of Medicine, Gyeongsang National University, Jinju 52727, Korea. [email protected].
  2. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O., Box 8044, Seoul 03722, Korea. [email protected].
  3. Division of Pediatric Nephrology, Severance Children's Hospital, Seoul 03722, Korea. [email protected].
  4. Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul 03722, Korea. [email protected].
  5. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O., Box 8044, Seoul 03722, Korea. [email protected].
  6. Division of Pediatric Nephrology, Severance Children's Hospital, Seoul 03722, Korea. [email protected].
  7. Wonkwang University School of Medicine, Iksan 54538, Korea. [email protected].
  8. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O., Box 8044, Seoul 03722, Korea. [email protected].
  9. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O., Box 8044, Seoul 03722, Korea. [email protected].
  10. Department of Internal Medicine IV (Nephrology and Hypertension), Medical University Innsbruck, 6020 Innsbruck, Austria. [email protected].
  11. Luton& Dunstable University Hospital NHS Foundation Trust, Lewsey Road, Luton LU4 ODZ, UK. [email protected].
  12. Department of Medical Oncology, Amsterdam UMC, Cancer Center Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands. [email protected].
  13. Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo 11566, Egypt. [email protected].
  14. Department of Oncology, University of Calgary, Tom Baker Cancer Centre, Calgary, AB T2N 1N4, Canada. [email protected].
  15. Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK. [email protected].
  16. South London and Maudsley NHS Foundation Trust, Denmark Hill, London SE5 8AZ, UK. [email protected].
  17. Faculty of Health, Social Care and Education, Anglia Ruskin University, Chelmsford CM1 1SQ, UK. [email protected].
  18. Department of Neuroscience, University of Padova, 35121 Padova, Italy. [email protected].
  19. National Research Council, Neuroscience Institute, 35128 Padova, Italy. [email protected].
  20. Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, SE-581 85 Linköping, Sweden. [email protected].
  21. Parc Sanitari Sant Joan de Déu/CIBERSAM, Universitat de Barcelona, Fundació Sant Joan de Déu, Sant Boi de Llobregat, 08830 Barcelona, Spain. [email protected].
  22. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), 08036 Barcelona, Spain. [email protected].
  23. Mental Health Research Networking Center (CIBERSAM), 08036 Barcelona, Spain. [email protected].
  24. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK. [email protected].
  25. Centre for Psychiatric Research, Department of Clinical Neuroscience, Karolinska Institutet, 113 30 Stockholm, Sweden. [email protected].
  26. Department of Pediatrics, Yonsei University College of Medicine, Yonsei-ro 50, Seodaemun-gu, C.P.O., Box 8044, Seoul 03722, Korea. [email protected].
  27. Division of Pediatric Nephrology, Severance Children's Hospital, Seoul 03722, Korea. [email protected].
  28. Institute of Kidney Disease Research, Yonsei University College of Medicine, Seoul 03722, Korea. [email protected].

PMID: 30691103 PMCID: PMC6406478 DOI: 10.3390/jcm8020143

Abstract

Capillary leak syndrome (CLS) is a rare disease with profound vascular leakage, which can be associated with a high mortality. There have been several reports on CLS as an adverse effect of anti-cancer agents and therapy, but the incidence of CLS according to the kinds of anti-cancer drugs has not been systemically evaluated. Thus, the aim of our study was to comprehensively meta-analyze the incidence of CLS by different types of cancer treatment or after bone marrow transplantation (BMT). We searched the literatures (inception to July 2018) and among 4612 articles, 62 clinical trials (studies) were eligible. We extracted the number of patients with CLS, total cancer patients, name of therapeutic agent and dose, and type of cancer. We performed a meta-analysis to estimate the summary effects with 95% confidence interval and between-study heterogeneity. The reported incidence of CLS was categorized by causative drugs and BMT. The largest number of studies reported on CLS incidence during interleukin-2 (IL-2) treatment (

Keywords: anti-CD agents; bone marrow transplantation; cancer; capillary leak syndrome; interleukin-2

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