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Feyz L, Henneman M, Verzijlbergen F, et al. Renal sympathetic denervation in patients with vasospastic angina. J Nucl Cardiol. 2019;27(6):2202-2209doi: 10.1007/s12350-019-01598-y.
Feyz, L., Henneman, M., Verzijlbergen, F., Kardys, I., Van Mieghem, N. M., & Daemen, J. (2020). Renal sympathetic denervation in patients with vasospastic angina. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 27(6), 2202-2209. https://doi.org/10.1007/s12350-019-01598-y
Feyz, Lida, et al. "Renal sympathetic denervation in patients with vasospastic angina." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology vol. 27,6 (2020): 2202-2209. doi: https://doi.org/10.1007/s12350-019-01598-y
Feyz L, Henneman M, Verzijlbergen F, Kardys I, Van Mieghem NM, Daemen J. Renal sympathetic denervation in patients with vasospastic angina. J Nucl Cardiol. 2020 Dec;27(6):2202-2209. doi: 10.1007/s12350-019-01598-y. Epub 2019 Feb 13. PMID: 30761478; PMCID: PMC7749092.
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J Nucl Cardiol. 2020 Dec;27(6):2202-2209. doi: 10.1007/s12350-019-01598-y. Epub 2019 Feb 13.

Renal sympathetic denervation in patients with vasospastic angina.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Lida Feyz, Maureen Henneman, Fred Verzijlbergen, Isabella Kardys, Nicolas M Van Mieghem, Joost Daemen

Affiliations

  1. Department of Cardiology, Thoraxcenter, Erasmus Medical Center, P.O. Box 2040, 3000, CA Rotterdam, The Netherlands.
  2. Department of Radiology and Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
  3. Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
  4. Department of Cardiology, Thoraxcenter, Erasmus Medical Center, P.O. Box 2040, 3000, CA Rotterdam, The Netherlands. [email protected].

PMID: 30761478 PMCID: PMC7749092 DOI: 10.1007/s12350-019-01598-y

Abstract

BACKGROUND: Sympathetic overactivity has been linked to vasospastic angina (VSA), although the exact pathophysiology of VSA is poorly understood. The purpose of this study is to assess if renal sympathetic denervation (RDN) reduces cardiac sympathetic nerve activity with a subsequent beneficial effect on angina relief in patients with refractory VSA.

METHODS AND RESULTS: Cardiac sympathetic nerve activity was assessed prior to procedure and at 6 months post-procedure using iodine-123 labeled meta-iodobenzylguanidine (

CONCLUSION: RDN resulted in improvements in angina class and quality of life at 6 months in patients with refractory VSA. RDN, however, did not result in significant changes in cardiac sympathetic nerve activity as measured using

Keywords: MIBG; Renal sympathetic denervation; meta-iodobenzylguanidine; quality of life; vasospastic angina

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