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Silverio A, Polito MV, Pace L, et al. Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging. J Nucl Cardiol. 2019;28(1):72-85doi: 10.1007/s12350-019-01637-8.
Silverio, A., Polito, M. V., Pace, L., D'Auria, F., Vitulano, G., Scarano, M., Citro, R., Galasso, G., & Piscione, F. (2021). Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 28(1), 72-85. https://doi.org/10.1007/s12350-019-01637-8
Silverio, Angelo, et al. "Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging." Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology vol. 28,1 (2021): 72-85. doi: https://doi.org/10.1007/s12350-019-01637-8
Silverio A, Polito MV, Pace L, D'Auria F, Vitulano G, Scarano M, Citro R, Galasso G, Piscione F. Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging. J Nucl Cardiol. 2021 Feb;28(1):72-85. doi: 10.1007/s12350-019-01637-8. Epub 2019 Feb 13. PMID: 30761483.
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J Nucl Cardiol. 2021 Feb;28(1):72-85. doi: 10.1007/s12350-019-01637-8. Epub 2019 Feb 13.

Predictors of outcome in patients with de novo diagnosis of heart failure with reduced ejection fraction: Role of combined myocardial and lung Iodine-123 Meta-Iodobenzylguanidine imaging.

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology

Angelo Silverio, Maria Vincenza Polito, Leonardo Pace, Federica D'Auria, Gennaro Vitulano, Massimo Scarano, Rodolfo Citro, Gennaro Galasso, Federico Piscione

Affiliations

  1. U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
  2. Dipartimento di Medicina, Chirurgia ed Odontoiatria "Scuola Medica Salernitana", Università degli Studi di Salerno, Fisciano, Italy.
  3. U.O.C. Medicina Nucleare, Dipartimento di Diagnostica per Immagini e Radioterapia, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.
  4. U.O.C. Cardiologia, Dipartimento Cardio-Toraco-Vascolare, A.O.U. San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy. [email protected].
  5. Dipartimento di Medicina, Chirurgia ed Odontoiatria "Scuola Medica Salernitana", Università degli Studi di Salerno, Fisciano, Italy. [email protected].

PMID: 30761483 DOI: 10.1007/s12350-019-01637-8

Abstract

BACKGROUND: The predictors of outcome in patients with de novo diagnosis of heart failure (HF) with reduced ejection fraction (HFrEF) are poorly known.

METHODS AND RESULTS: All consecutive HFrEF patients admitted between October 2012 and November 2017 with their first episode of HF were scheduled for an outpatient follow-up. After 3 months, patients with confirmed HFrEF underwent Iodine-123 Meta-Iodobenzylguanidine imaging. We defined three study endpoints: HF rehospitalization, cardiac death and all-cause death. Eighty-four patients were enrolled. During follow-up (39.9 ± 18.6 months) HF rehospitalization occurred in 33 cases, cardiac death in 18 and all-cause death in 24. At multivariate analysis, systolic pulmonary arterial pressure (sPAP; HR: 1.047; p = .027) and Late lung to heart ratio (L/H; HR: 1.341; p < .001) independently predict HF rehospitalization; left ventricular end-systolic volume (LVESV; HR: 1.016; p = .017), sPAP (HR: 1.064; p = .034) and Late L/H (HR: 1.323; p = .009) were predictors of cardiac death; LVESV (HR: 1.013; p = .018) and Late L/H (HR: 1.245; p = .012) were independent predictors of all-cause death. Kaplan-Meier analysis of the individual predictors confirmed their prognostic ability during follow-up; of note, the Late L/H cut-off of 1.1 improved the risk stratification capability of echocardiographic parameters.

CONCLUSIONS: Late L/H independently predicts HF rehospitalization, cardiac death and all-cause death in patients with de novo diagnosis of HFrEF and improves the prognostic stratification capability of conventional echocardiographic parameters.

Keywords: Heart failure; Iodine-123 Meta-Iodobenzylguanidine; echocardiography; single-photon emission computed tomography

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