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Salari M, Salari R, Rafatpanah H, et al. Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls. Avicenna J Phytomed. 2019;9(1):54-61
Salari, M., Salari, R., Rafatpanah, H., Ravanshad, Y., Zirachi, D., & Sahebari, M. (2019). Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls. Avicenna journal of phytomedicine, 9(1), 54-61.
Salari, Masoumeh, et al. "Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls." Avicenna journal of phytomedicine vol. 9,1 (2019): 54-61.
Salari M, Salari R, Rafatpanah H, Ravanshad Y, Zirachi D, Sahebari M. Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls. Avicenna J Phytomed. 2019 Jan-Feb;9(1):54-61. PMID: 30788278; PMCID: PMC6369324.
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Avicenna J Phytomed. 2019 Jan-Feb;9(1):54-61.

Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls.

Avicenna journal of phytomedicine

Masoumeh Salari, Roshanak Salari, Houshang Rafatpanah, Yalda Ravanshad, Danial Zirachi, Maryam Sahebari

Affiliations

  1. Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  2. Department of Traditional Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  3. Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  4. Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 30788278 PMCID: PMC6369324

Abstract

OBJECTIVE: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients.

MATERIALS AND METHODS: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experiment. The subjects in case group were calcified to newly diagnosed patients and those previously diagnosed with RA. A topical solution of capsaicin (0.075%) was applied on the volar forearm during the skin test, and evaluations were done after 5, 10, and 20 min. The parameters recorded in capsaicin skin test were time to tingling, area of induration (cm

RESULTS: A faster capsaicin skin reaction was observed in healthy controls compared to the case group (p=0.02). Newly diagnosed and previously diagnosed RA patients were not significantly different in terms of reaction latency (p=0.06). The redness area after 15 (p=0.04) and 20 (p=0.001) min was significantly larger in previously diagnosed RA patients than in newly diagnosed ones. The ​​area of redness and time to tingling did not show any difference between active and inactive RA patients, but after 15 and 20 min, the area of redness was significantly greater in inactive RA patients compared to active RA patients (p=0.01 and p=0.03, respectively).

CONCLUSION: This study suggested that capsaicin skin test is not an efficient tool for the examination of synovial inflammation and disease activity in RA.

Keywords: Capsaicin; Inflammation; Rheumatoid arthritis

Conflict of interest statement

None declared.

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