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Silva RMFLD, Miranda CM, Liu T, et al. Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation. Front Neurosci. 2019;13:18doi: 10.3389/fnins.2019.00018.
Silva, R. M. F. L. D., Miranda, C. M., Liu, T., Tse, G., & Roever, L. (2019). Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation. Frontiers in neuroscience, 1318. https://doi.org/10.3389/fnins.2019.00018
Silva, Rose Mary Ferreira Lisboa Da, et al. "Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation." Frontiers in neuroscience vol. 13 (2019): 18. doi: https://doi.org/10.3389/fnins.2019.00018
Silva RMFLD, Miranda CM, Liu T, Tse G, Roever L. Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation. Front Neurosci. 2019 Jan 31;13:18. doi: 10.3389/fnins.2019.00018. eCollection 2019. PMID: 30766470; PMCID: PMC6365433.
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Front Neurosci. 2019 Jan 31;13:18. doi: 10.3389/fnins.2019.00018. eCollection 2019.

Atrial Fibrillation and Risk of Dementia: Epidemiology, Mechanisms, and Effect of Anticoagulation.

Frontiers in neuroscience

Rose Mary Ferreira Lisboa Da Silva, Cláudia Madeira Miranda, Tong Liu, Gary Tse, Leonardo Roever

Affiliations

  1. Department of Internal Medicine, Federal Institute of Minas Gerais, Belo Horizonte, Brazil.
  2. Department of Cardiology, Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin, China.
  3. Department of Medicine and Therapeutics, The University of Hong Kong, Pokfulam, Hong Kong.
  4. Department of Clinical Research, Federal University of Uberlandia, Uberlândia, Brazil.

PMID: 30766470 PMCID: PMC6365433 DOI: 10.3389/fnins.2019.00018

Abstract

Atrial fibrillation (AF) is one of the cardiovascular risk factors for dementia. Several longitudinal studies have reported an association between AF and dementia independently of stroke history. Although the mechanisms underlying this association are not fully understood, proposed mechanisms include cerebral hypoperfusion, inflammation, genetic factors, cerebral microbleeds, and recurrent silent cerebral ischemia. Oral anticoagulation can be used to minimize risk of cognitive decline and dementia, given that brain insults can be caused by chronic microemboli or microbleeds. However, controversy on the effects of warfarin and direct oral anticoagulants on this risk exists. This article will address these aspects, with data on the studies already published and a critical view on this subject.

Keywords: Alzheimer's disease; anticoagulation therapy; atrial fibrillation; cognition; dementia

References

  1. J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):268-74 - PubMed
  2. Am J Cardiol. 2006 Nov 1;98(9):1238-41 - PubMed
  3. Arch Gerontol Geriatr. 2007;44 Suppl 1:155-65 - PubMed
  4. Eur Heart J. 2007 Aug;28(16):1962-7 - PubMed
  5. J Stroke Cerebrovasc Dis. 2006 Sep-Oct;15(5):214-22 - PubMed
  6. J Hypertens. 2009 Oct;27(10):2055-62 - PubMed
  7. Neurobiol Aging. 2011 Jul;32(7):1336-7 - PubMed
  8. Heart Rhythm. 2010 Apr;7(4):433-7 - PubMed
  9. Circ Cardiovasc Qual Outcomes. 2010 May;3(3):277-83 - PubMed
  10. Neurology. 2011 Mar 8;76(10):914-22 - PubMed
  11. J Am Geriatr Soc. 2011 Aug;59(8):1369-75 - PubMed
  12. Dialogues Clin Neurosci. 2003 Mar;5(1):101-8 - PubMed
  13. CMAJ. 2012 Apr 3;184(6):E329-36 - PubMed
  14. J Am Geriatr Soc. 2012 Aug;60(8):1509-14 - PubMed
  15. Heart Rhythm. 2012 Nov;9(11):1761-8 - PubMed
  16. Arq Bras Cardiol. 2012 Dec;99(6):1108-14 - PubMed
  17. Ann Intern Med. 2013 Mar 5;158(5 Pt 1):338-46 - PubMed
  18. J Am Coll Cardiol. 2013 Aug 6;62(6):531-9 - PubMed
  19. QJM. 2013 Sep;106(9):795-802 - PubMed
  20. Neurology. 2013 Jul 9;81(2):119-25 - PubMed
  21. J Am Heart Assoc. 2013 Dec 18;2(6):e000369 - PubMed
  22. J Alzheimers Dis. 2014;42(1):183-91 - PubMed
  23. Lancet Neurol. 2014 Aug;13(8):788-94 - PubMed
  24. Clin Geriatr Med. 2014 Aug;30(3):421-42 - PubMed
  25. Heart Rhythm. 2014 Dec;11(12):2206-13 - PubMed
  26. Nat Rev Cardiol. 2014 Nov;11(11):639-54 - PubMed
  27. Geriatr Gerontol Int. 2015 Jun;15(6):770-7 - PubMed
  28. Trends Cardiovasc Med. 2015 Jan;25(1):44-51 - PubMed
  29. Nat Rev Cardiol. 2015 May;12(5):267-77 - PubMed
  30. Int J Cardiol. 2015 Nov 15;199:25-30 - PubMed
  31. JAMA Neurol. 2015 Nov;72(11):1288-94 - PubMed
  32. Stroke. 2016 Mar;47(3):895-900 - PubMed
  33. Lancet. 2016 Jul 30;388(10043):505-17 - PubMed
  34. Int J Cardiol. 2016 Oct 1;220:440-4 - PubMed
  35. Age Ageing. 2016 Nov;45(6):767-775 - PubMed
  36. Eur Heart J. 2016 Oct 7;37(38):2893-2962 - PubMed
  37. Heart Rhythm. 2017 May;14(5):635-642 - PubMed
  38. Europace. 2018 Mar 1;20(3):408-419 - PubMed
  39. Prog Cardiovasc Dis. 2017 May - Jun;59(6):626-635 - PubMed
  40. Eur Heart J. 2017 Sep 7;38(34):2612-2618 - PubMed
  41. Stroke. 2017 Aug;48(8):2066-2072 - PubMed
  42. J Am Heart Assoc. 2017 Jul 24;6(7):null - PubMed
  43. Int J Cardiol. 2017 Oct 15;245:181-182 - PubMed
  44. Lancet. 2017 Sep 16;390(10100):1211-1259 - PubMed
  45. Heart Rhythm. 2018 Feb;15(2):166-172 - PubMed
  46. Int J Cardiol. 2018 Jan 1;250:152-156 - PubMed
  47. Can J Cardiol. 2017 Dec;33(12):1556-1564 - PubMed
  48. Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):1-9 - PubMed
  49. J Am Heart Assoc. 2018 Mar 7;7(6):null - PubMed
  50. J Cardiovasc Pharmacol. 2018 Jun;71(6):380-387 - PubMed
  51. Europace. 2018 Sep 1;20(9):1399-1421 - PubMed
  52. Int J Cardiol. 2018 Jun 1;260:112 - PubMed
  53. Nat Rev Cardiol. 2018 Dec;15(12):744-756 - PubMed
  54. Neurology. 2018 Nov 6;91(19):e1732-e1740 - PubMed
  55. Neurosci Biobehav Rev. 2019 Jan;96:1-9 - PubMed
  56. Postgrad Med J. 1985 Mar;61(713):201-4 - PubMed
  57. Stroke. 1997 Feb;28(2):316-21 - PubMed

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