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Dulińska-Litewka J, Łazarczyk A, Hałubiec P, et al. Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications. Materials (Basel). 2019;12(4)doi: 10.3390/ma12040617.
Dulińska-Litewka, J., Łazarczyk, A., Hałubiec, P., Szafrański, O., Karnas, K., & Karewicz, A. (2019). Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications. Materials (Basel, Switzerland), 12(4), . https://doi.org/10.3390/ma12040617
Dulińska-Litewka, Joanna, et al. "Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications." Materials (Basel, Switzerland) vol. 12,4 (2019). doi: https://doi.org/10.3390/ma12040617
Dulińska-Litewka J, Łazarczyk A, Hałubiec P, Szafrański O, Karnas K, Karewicz A. Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications. Materials (Basel). 2019 Feb 19;12(4). doi: 10.3390/ma12040617. PMID: 30791358; PMCID: PMC6416629.
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Materials (Basel). 2019 Feb 19;12(4). doi: 10.3390/ma12040617.

Superparamagnetic Iron Oxide Nanoparticles-Current and Prospective Medical Applications.

Materials (Basel, Switzerland)

Joanna Dulińska-Litewka, Agnieszka Łazarczyk, Przemysław Hałubiec, Oskar Szafrański, Karolina Karnas, Anna Karewicz

Affiliations

  1. Chair of Medical Biochemistry, Jagiellonian University Medical College, 7 Kopernika St., 31-034 Kraków, Poland. [email protected].
  2. Chair of Medical Biochemistry, Jagiellonian University Medical College, 7 Kopernika St., 31-034 Kraków, Poland. [email protected].
  3. Chair of Medical Biochemistry, Jagiellonian University Medical College, 7 Kopernika St., 31-034 Kraków, Poland. [email protected].
  4. Chair of Medical Biochemistry, Jagiellonian University Medical College, 7 Kopernika St., 31-034 Kraków, Poland. [email protected].
  5. Department of Chemistry, Jagiellonian University, 2 Gronostajowa St., 30-387 Kraków, Poland. [email protected].
  6. Department of Chemistry, Jagiellonian University, 2 Gronostajowa St., 30-387 Kraków, Poland. [email protected].

PMID: 30791358 PMCID: PMC6416629 DOI: 10.3390/ma12040617

Abstract

The recent, fast development of nanotechnology is reflected in the medical sciences. Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are an excellent example. Thanks to their superparamagnetic properties, SPIONs have found application in Magnetic Resonance Imaging (MRI) and magnetic hyperthermia. Unlike bulk iron, SPIONs do not have remnant magnetization in the absence of the external magnetic field; therefore, a precise remote control over their action is possible. This makes them also useful as a component of the advanced drug delivery systems. Due to their easy synthesis, biocompatibility, multifunctionality, and possibility of further surface modification with various chemical agents, SPIONs could support many fields of medicine. SPIONs have also some disadvantages, such as their high uptake by macrophages. Nevertheless, based on the ongoing studies, they seem to be very promising in oncological therapy (especially in the brain, breast, prostate, and pancreatic tumors). The main goal of our paper is, therefore, to present the basic properties of SPIONs, to discuss their current role in medicine, and to review their applications in order to inspire future developments of new, improved SPION systems.

Keywords: MRI; SPION; antibodies; hyperthermia; iron oxide; toxicity

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