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Kovtunov KV, Kidd BE, Salnikov OG, et al. Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner. J Phys Chem C Nanomater Interfaces. 2017;121(46):25994-25999doi: 10.1021/acs.jpcc.7b10549.
Kovtunov, K. V., Kidd, B. E., Salnikov, O. G., Bales, L. B., Gemeinhardt, M. E., Gesiorski, J., Shchepin, R. V., Chekmenev, E. Y., Goodson, B. M., & Koptyug, I. V. (2017). Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner. The journal of physical chemistry. C, Nanomaterials and interfaces, 121(46), 25994-25999. https://doi.org/10.1021/acs.jpcc.7b10549
Kovtunov, Kirill V, et al. "Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner." The journal of physical chemistry. C, Nanomaterials and interfaces vol. 121,46 (2017): 25994-25999. doi: https://doi.org/10.1021/acs.jpcc.7b10549
Kovtunov KV, Kidd BE, Salnikov OG, Bales LB, Gemeinhardt ME, Gesiorski J, Shchepin RV, Chekmenev EY, Goodson BM, Koptyug IV. Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner. J Phys Chem C Nanomater Interfaces. 2017 Nov 22;121(46):25994-25999. doi: 10.1021/acs.jpcc.7b10549. Epub 2017 Nov 01. PMID: 30701013; PMCID: PMC6349396.
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J Phys Chem C Nanomater Interfaces. 2017 Nov 22;121(46):25994-25999. doi: 10.1021/acs.jpcc.7b10549. Epub 2017 Nov 01.

Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner.

The journal of physical chemistry. C, Nanomaterials and interfaces

Kirill V Kovtunov, Bryce E Kidd, Oleg G Salnikov, Liana B Bales, Max E Gemeinhardt, Jonathan Gesiorski, Roman V Shchepin, Eduard Y Chekmenev, Boyd M Goodson, Igor V Koptyug

Affiliations

  1. International Tomography Center SB RAS, Novosibirsk, 630090, Russia.
  2. Novosibirsk State University, Novosibirsk, 630090, Russia.
  3. Department of Chemistry and Biochemistry, Southern Illinois University, Carbondale, IL 62901, USA.
  4. Vanderbilt Institute of Imaging Science (VUIIS), Department of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
  5. Russian Academy of Sciences, Moscow, 119991, Russia.
  6. Materials Technology Center, Southern Illinois University, Carbondale, IL 62901, USA.

PMID: 30701013 PMCID: PMC6349396 DOI: 10.1021/acs.jpcc.7b10549

Abstract

The Signal Amplification by Reversible Exchange (SABRE) technique employs exchange with singlet-state parahydrogen to efficiently generate high levels of nuclear spin polarization. Spontaneous SABRE has been shown previously to be efficient in the milli-Tesla and micro-Tesla regimes. We have recently demonstrated that high-field SABRE is also possible, where proton sites of molecules that are able to reversibly coordinate to a metal center can be hyperpolarized directly within high-field magnets, potentially offering the convenience of

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