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Chahine LM, Iranzo A, Fernández-Arcos A, et al. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinsons Dis. 2019;5:2doi: 10.1038/s41531-018-0073-1.
Chahine, L. M., Iranzo, A., Fernández-Arcos, A., Simuni, T., Seedorff, N., Caspell-Garcia, C., Amara, A. W., Comella, C., Högl, B., Hamilton, J., Marek, K., Mayer, G., Mollenhauer, B., Postuma, R., Tolosa, E., Trenkwalder, C., Videnovic, A., Oertel, W. (2019). Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinson's disease, 52. https://doi.org/10.1038/s41531-018-0073-1
Chahine, L M, et al. "Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder." NPJ Parkinson's disease vol. 5 (2019): 2. doi: https://doi.org/10.1038/s41531-018-0073-1
Chahine LM, Iranzo A, Fernández-Arcos A, Simuni T, Seedorff N, Caspell-Garcia C, Amara AW, Comella C, Högl B, Hamilton J, Marek K, Mayer G, Mollenhauer B, Postuma R, Tolosa E, Trenkwalder C, Videnovic A, Oertel W. Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder. NPJ Parkinsons Dis. 2019 Jan 29;5:2. doi: 10.1038/s41531-018-0073-1. eCollection 2019. PMID: 30701189; PMCID: PMC6351563.
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NPJ Parkinsons Dis. 2019 Jan 29;5:2. doi: 10.1038/s41531-018-0073-1. eCollection 2019.

Basic clinical features do not predict dopamine transporter binding in idiopathic REM behavior disorder.

NPJ Parkinson's disease

L M Chahine, A Iranzo, A Fernández-Arcos, T Simuni, N Seedorff, C Caspell-Garcia, A W Amara, C Comella, B Högl, J Hamilton, K Marek, G Mayer, B Mollenhauer, R Postuma, E Tolosa, C Trenkwalder, A Videnovic, W Oertel,

Affiliations

  1. 1Department of Neurology, The University of Pittsburgh, Pittsburgh, PA USA.
  2. Neurology Service, Hospital Clinic de Barcelona, IDIBAPS, CIBERNED, Barcelona, Spain.
  3. 3Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL USA.
  4. 4Department of Biostatistics, The University of Iowa, Iowa City, IA USA.
  5. 5Department of Neurology, The University of Alabama at Birmingham, Birmingham, AL USA.
  6. 6Department of Neurology, Rush University, Chicago, IL USA.
  7. 7Department of Neurology, Innsbruck Medical University, Innsbruck, Austria.
  8. 8The Michael J. Fox Foundation for Parkinson's Research, New York, NY USA.
  9. 9Institute for Neurodegenerative Disorders, New Haven, CT USA.
  10. Department of Neurology, Hephata-Klinik, Hephata Hessisches Diakoniezentrum, e.V, Weibersbrunn, Germany.
  11. 11Department of Neurology, University Medical Center, Göttingen, Germany.
  12. 12Paracelsus-Elena-Klinik, Kassel, Germany.
  13. 13Division of Neurology, McGill University, Montreal, QC Canada.
  14. 14Department of Neurology, Massachusetts General Hospital, Boston, MA USA.
  15. 15Department of Neurology, Philipps University, Marburg, Germany.
  16. 16Charitable Hertie Foundation, Frankfurt/Main, Germany.

PMID: 30701189 PMCID: PMC6351563 DOI: 10.1038/s41531-018-0073-1

Abstract

REM sleep behavior disorder (RBD) is strongly associated with development of Parkinson's Disease and other α-synuclein-related disorders. Dopamine transporter (DAT) binding deficit predicts conversion to α-synuclein-related disorders in individuals with RBD. In turn, identifying which individuals with RBD have the highest likelihood of having abnormal DAT binding would be useful. The objective of this analysis was to examine if there are basic clinical predictors of DAT deficit in RBD. Participants referred for inclusion in the RBD cohort of the Parkinson Progression Markers Initiative were included. Assessments at the screening visit including DAT SPECT imaging, physical examination, cognitive function screen, and questionnaire-based non-motor assessment. The group with DAT binding deficit (

Conflict of interest statement

The authors declare no competing interests.

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