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Pozzoli G, Marei HE, Althani A, et al. Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation. J Cell Physiol. 2019;doi: 10.1002/jcp.28194.
Pozzoli, G., Marei, H. E., Althani, A., Boninsegna, A., Casalbore, P., Marlier, L. N. J. L., Lanzilli, G., Zonfrillo, M., Petrucci, G., Rocca, B., Navarra, P., Sgambato, A., & Cenciarelli, C. (2019). Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation. Journal of cellular physiology, . https://doi.org/10.1002/jcp.28194
Pozzoli, Giacomo, et al. "Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation." Journal of cellular physiology vol. (2019). doi: https://doi.org/10.1002/jcp.28194
Pozzoli G, Marei HE, Althani A, Boninsegna A, Casalbore P, Marlier LNJL, Lanzilli G, Zonfrillo M, Petrucci G, Rocca B, Navarra P, Sgambato A, Cenciarelli C. Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation. J Cell Physiol. 2019 Jan 30; doi: 10.1002/jcp.28194. Epub 2019 Jan 30. PMID: 30701538.
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J Cell Physiol. 2019 Jan 30; doi: 10.1002/jcp.28194. Epub 2019 Jan 30.

Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.

Journal of cellular physiology

Giacomo Pozzoli, Hany E Marei, Asma Althani, Alma Boninsegna, Patrizia Casalbore, Lionel N J L Marlier, Giulia Lanzilli, Manuela Zonfrillo, Giovanna Petrucci, Bianca Rocca, Pierluigi Navarra, Alessandro Sgambato, Carlo Cenciarelli

Affiliations

  1. Institute of Pharmacology, Università Cattolica del Sacro Cuore, Rome, Italy.
  2. Pharmacology Unit, Fondazione Policlinico A. Gemelli IRCCS, Rome, Italy.
  3. Department of Cytology and Histology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt.
  4. Biomedical Research Center, Qatar University, Doha, Qatar.
  5. Institute of General Pathology, Università Cattolica del Sacro Cuore, Rome, Italy.
  6. Department of Biomedical Sciences, Institute of Cell Biology and Neurobiology (IBCN), National Research Council (CNR), Rome, Italy.
  7. Department of Biomedical Sciences, Institute of Translational Pharmacology (IFT), National Research Council (CNR), Rome, Italy.

PMID: 30701538 DOI: 10.1002/jcp.28194

Abstract

Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent antitumor effects have also been described. Here we report, for the first time, that aspirin treatment of human glioblastoma cancer (GBM) stem cells, a small population responsible for tumor progression and recurrence, is associated with reduced cell proliferation and motility. Aspirin did not interfere with cell viability but induced cell-cycle arrest. Exogenous prostaglandin E

© 2019 Wiley Periodicals, Inc.

Keywords: CSC; Cox; GBM; Rb1; aspirin; stemness

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