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Daddi-Moussa-Ider A, Goh S, Liebchen B, et al. Membrane penetration and trapping of an active particle. J Chem Phys. 2019;150(6):064906doi: 10.1063/1.5080807.
Daddi-Moussa-Ider, A., Goh, S., Liebchen, B., Hoell, C., Mathijssen, A. J. T. M., Guzmán-Lastra, F., Scholz, C., Menzel, A. M., & Löwen, H. (2019). Membrane penetration and trapping of an active particle. The Journal of chemical physics, 150(6), 064906. https://doi.org/10.1063/1.5080807
Daddi-Moussa-Ider, Abdallah, et al. "Membrane penetration and trapping of an active particle." The Journal of chemical physics vol. 150,6 (2019): 064906. doi: https://doi.org/10.1063/1.5080807
Daddi-Moussa-Ider A, Goh S, Liebchen B, Hoell C, Mathijssen AJTM, Guzmán-Lastra F, Scholz C, Menzel AM, Löwen H. Membrane penetration and trapping of an active particle. J Chem Phys. 2019 Feb 14;150(6):064906. doi: 10.1063/1.5080807. PMID: 30770004.
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J Chem Phys. 2019 Feb 14;150(6):064906. doi: 10.1063/1.5080807.

Membrane penetration and trapping of an active particle.

The Journal of chemical physics

Abdallah Daddi-Moussa-Ider, Segun Goh, Benno Liebchen, Christian Hoell, Arnold J T M Mathijssen, Francisca Guzmán-Lastra, Christian Scholz, Andreas M Menzel, Hartmut Löwen

Affiliations

  1. Institut für Theoretische Physik II: Weiche Materie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany.
  2. Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, California 94305, USA.

PMID: 30770004 DOI: 10.1063/1.5080807

Abstract

The interaction between nano- or micro-sized particles and cell membranes is of crucial importance in many biological and biomedical applications such as drug and gene delivery to cells and tissues. During their cellular uptake, the particles can pass through cell membranes via passive endocytosis or by active penetration to reach a target cellular compartment or organelle. In this manuscript, we develop a simple model to describe the interaction of a self-driven spherical particle (moving through an effective constant active force) with a minimal membrane system, allowing for both penetration and trapping. We numerically calculate the state diagram of this system, the membrane shape, and its dynamics. In this context, we show that the active particle may either get trapped near the membrane or penetrate through it, where the membrane can either be permanently destroyed or recover its initial shape by self-healing. Additionally, we systematically derive a continuum description allowing us to accurately predict most of our results analytically. This analytical theory helps in identifying the generic aspects of our model, suggesting that most of its ingredients should apply to a broad range of membranes, from simple model systems composed of magnetic microparticles to lipid bilayers. Our results might be useful to predict the mechanical properties of synthetic minimal membranes.

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