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Li S, Gao D, Jiang Y. Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma. Metabolites. 2019;9(2)doi: 10.3390/metabo9020036.
Li, S., Gao, D., & Jiang, Y. (2019). Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma. Metabolites, 9(2), . https://doi.org/10.3390/metabo9020036
Li, Shangfu, et al. "Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma." Metabolites vol. 9,2 (2019). doi: https://doi.org/10.3390/metabo9020036
Li S, Gao D, Jiang Y. Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma. Metabolites. 2019 Feb 21;9(2). doi: 10.3390/metabo9020036. PMID: 30795537; PMCID: PMC6410233.
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Metabolites. 2019 Feb 21;9(2). doi: 10.3390/metabo9020036.

Function, Detection and Alteration of Acylcarnitine Metabolism in Hepatocellular Carcinoma.

Metabolites

Shangfu Li, Dan Gao, Yuyang Jiang

Affiliations

  1. State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. [email protected].
  2. National & Local United Engineering Lab for Personalized Anti-tumour Drugs, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. [email protected].
  3. State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. [email protected].
  4. National & Local United Engineering Lab for Personalized Anti-tumour Drugs, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. [email protected].
  5. Key Laboratory of Metabolomics at Shenzhen, Shenzhen 518055, China. [email protected].
  6. State Key Laboratory of Chemical Oncogenomics, Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China. [email protected].
  7. School of Pharmaceutical Sciences, Tsinghua University, Beijing 100084, China. [email protected].

PMID: 30795537 PMCID: PMC6410233 DOI: 10.3390/metabo9020036

Abstract

Acylcarnitines play an essential role in regulating the balance of intracellular sugar and lipid metabolism. They serve as carriers to transport activated long-chain fatty acids into mitochondria for β-oxidation as a major source of energy for cell activities. The liver is the most important organ for endogenous carnitine synthesis and metabolism. Hepatocellular carcinoma (HCC), a primary malignancy of the live with poor prognosis, may strongly influence the level of acylcarnitines. In this paper, the function, detection and alteration of acylcarnitine metabolism in HCC were briefly reviewed. An overview was provided to introduce the metabolic roles of acylcarnitines involved in fatty acid β-oxidation. Then different analytical platforms and methodologies were also briefly summarised. The relationship between HCC and acylcarnitine metabolism was described. Many of the studies reported that short, medium and long-chain acylcarnitines were altered in HCC patients. These findings presented current evidence in support of acylcarnitines as new candidate biomarkers for studies on the pathogenesis and development of HCC. Finally we discussed the challenges and perspectives of exploiting acylcarnitine metabolism and its related metabolic pathways as a target for HCC diagnosis and prognosis.

Keywords: acylcarnitines; hepatocellular carcinoma; metabolite profiling; metabolomics

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