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Hofman P, Ayache N, Barbry P, et al. The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again. Cancers (Basel). 2019;11(2)doi: 10.3390/cancers11020250.
Hofman, P., Ayache, N., Barbry, P., Barlaud, M., Bel, A., Blancou, P., Checler, F., Chevillard, S., Cristofari, G., Demory, M., Esnault, V., Falandry, C., Gilson, E., Guérin, O., Glaichenhaus, N., Guigay, J., Ilié, M., Mari, B., Marquette, C. H., Paquis-Flucklinger, V., Prate, F., Saintigny, P., Seitz-Polsky, B., Skhiri, T., Van Obberghen-Schilling, E., Van Obberghen, E., & Yvan-Charvet, L. (2019). The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again. Cancers, 11(2), . https://doi.org/10.3390/cancers11020250
Hofman, Paul, et al. "The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again." Cancers vol. 11,2 (2019). doi: https://doi.org/10.3390/cancers11020250
Hofman P, Ayache N, Barbry P, Barlaud M, Bel A, Blancou P, Checler F, Chevillard S, Cristofari G, Demory M, Esnault V, Falandry C, Gilson E, Guérin O, Glaichenhaus N, Guigay J, Ilié M, Mari B, Marquette CH, Paquis-Flucklinger V, Prate F, Saintigny P, Seitz-Polsky B, Skhiri T, Van Obberghen-Schilling E, Van Obberghen E, Yvan-Charvet L. The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again. Cancers (Basel). 2019 Feb 21;11(2). doi: 10.3390/cancers11020250. PMID: 30795607; PMCID: PMC6406685.
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Cancers (Basel). 2019 Feb 21;11(2). doi: 10.3390/cancers11020250.

The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again.

Cancers

Paul Hofman, Nicholas Ayache, Pascal Barbry, Michel Barlaud, Audrey Bel, Philippe Blancou, Frédéric Checler, Sylvie Chevillard, Gael Cristofari, Mathilde Demory, Vincent Esnault, Claire Falandry, Eric Gilson, Olivier Guérin, Nicolas Glaichenhaus, Joel Guigay, Marius Ilié, Bernard Mari, Charles-Hugo Marquette, Véronique Paquis-Flucklinger, Frédéric Prate, Pierre Saintigny, Barbara Seitz-Polsky, Taycir Skhiri, Ellen Van Obberghen-Schilling, Emmanuel Van Obberghen, Laurent Yvan-Charvet

Affiliations

  1. Laboratory of Clinical and Experimental Pathology/Biobank 0033-00025, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06001 Nice, France. [email protected].
  2. Inserm U1081, CNRS UMR7284, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  3. Epione Team, Inria, FHU OncoAge, Université Côte d'Azur, 06902 Sophia Antipolis, France. [email protected].
  4. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  5. i3S Sophia Antipolis, FHU OncoAge, Université Côte d'Azur, 06560 Sophia Antipolis, France. [email protected].
  6. Centre d'Innovation et d'Usages en Santé (CIUS), FHU OncoAge, Université Côte d'Azur, 06000 Nice, France. [email protected].
  7. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  8. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  9. Laboratoire de Cancérologie Expérimentale, Institut François Jacob, CEA Direction de la Recherche Fondamentale, FHU OncoAge, Université Côte d'Azur, 92265 Fontenay-aux-Roses, France. [email protected].
  10. Inserm U1081, CNRS UMR7284, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  11. Ville de Nice, Mairie de Nice, FHU OncoAge, Université Côte d'Azur, 06364 Nice, France. [email protected].
  12. Nephrology Department, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06001 Nice, France. [email protected].
  13. Geriatric Unit, Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, FHU OncoAge, Université Claude Bernard Lyon 1, 69310 Pierre-Benite, France. [email protected].
  14. Laboratoire CarMeN, Inserm U1060, INRA U139, INSA Lyon, Ecole de Médecine Charles Mérieux, Université Claude Bernard Lyon 1, 69921 Oullins, France. [email protected].
  15. Inserm U1081, CNRS UMR7284, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  16. Geriatric Coordination Unit for Geriatric Oncology (UCOG) PACA Est, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06000 Nice, France. [email protected].
  17. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  18. Oncology Department, Centre Antoine Lacassagne, FHU OncoAge, Université Côté d'Azur, 06189 Nice, France. [email protected].
  19. Laboratory of Clinical and Experimental Pathology/Biobank 0033-00025, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06001 Nice, France. [email protected].
  20. Inserm U1081, CNRS UMR7284, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  21. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  22. Department of Pulmonary Medicine and Oncology, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06000 Nice, France. [email protected].
  23. Inserm U1081, CNRS UMR7284, Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  24. Geriatric Coordination Unit for Geriatric Oncology (UCOG) PACA Est, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06000 Nice, France. [email protected].
  25. Département de Médecine, INSERM 1052, CNRS 5286, Centre de recherche en cancérologie de Lyon, Centre Léon Bérard, FHU OncoAge, Université Claude Bernard Lyon 1, 69008 Lyon, France. [email protected].
  26. CNRS UMR7275, Institut de Pharmacologie Cellulaire et Moléculaire, FHU OncoAge, Université Côte d'Azur, 06560 Valbonne, France. [email protected].
  27. Laboratory of Immunology, CHU Nice, FHU OncoAge, Université Côte d'Azur, 06200 Nice, France. [email protected].
  28. Centre d'Innovation et d'Usages en Santé (CIUS), FHU OncoAge, Université Côte d'Azur, 06000 Nice, France. [email protected].
  29. CNRS, Inserm, iBV, Centre Antoine Lacassagne, FHU OncoAge, Université Côte d'Azur, 06108 Nice, France. [email protected].
  30. CNRS, LP2M, FHU OncoAge, Université Côte d'Azur, 06107 Nice, France. [email protected].
  31. Inserm U1065, Centre Méditerranéen de Médecine Moléculaire (C3M), FHU OncoAge, Université Côte d'Azur, 06200 Nice, France. [email protected].

PMID: 30795607 PMCID: PMC6406685 DOI: 10.3390/cancers11020250

Abstract

It is generally accepted that carcinogenesis and aging are two biological processes, which are known to be associated. Notably, the frequency of certain cancers (including lung cancer), increases significantly with the age of patients and there is now a wealth of data showing that multiple mechanisms leading to malignant transformation and to aging are interconnected, defining the so-called common biology of aging and cancer. OncoAge, a consortium launched in 2015, brings together the multidisciplinary expertise of leading public hospital services and academic laboratories to foster the transfer of scientific knowledge rapidly acquired in the fields of cancer biology and aging into innovative medical practice and silver economy development. This is achieved through the development of shared technical platforms (for research on genome stability, (epi)genetics, biobanking, immunology, metabolism, and artificial intelligence), clinical research projects, clinical trials, and education. OncoAge focuses mainly on two pilot pathologies, which benefit from the expertise of several members, namely lung and head and neck cancers. This review outlines the broad strategic directions and key advances of OncoAge and summarizes some of the issues faced by this consortium, as well as the short- and long-term perspectives.

Keywords: aging; cancer; education; elderly; optimization; research; well-being

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