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Grotzer MA, Guerreiro AS, Bourquin JP, et al. IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system. Expert Rev Endocrinol Metab. 2007;2(5):677-688doi: 10.1586/17446651.2.5.677.
Grotzer, M. A., Guerreiro, A. S., Bourquin, J. P., & Arcaro, A. (2007). IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system. Expert review of endocrinology & metabolism, 2(5), 677-688. https://doi.org/10.1586/17446651.2.5.677
Grotzer, Michael A, et al. "IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system." Expert review of endocrinology & metabolism vol. 2,5 (2007): 677-688. doi: https://doi.org/10.1586/17446651.2.5.677
Grotzer MA, Guerreiro AS, Bourquin JP, Arcaro A. IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system. Expert Rev Endocrinol Metab. 2007 Sep;2(5):677-688. doi: 10.1586/17446651.2.5.677. PMID: 30736130.
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Expert Rev Endocrinol Metab. 2007 Sep;2(5):677-688. doi: 10.1586/17446651.2.5.677.

IGF signaling as a therapeutic target in pediatric solid tumors of the central and peripheral nervous system.

Expert review of endocrinology & metabolism

Michael A Grotzer, Ana S Guerreiro, Jean-Pierre Bourquin, Alexandre Arcaro

Affiliations

  1. a University Children's Hospital of Zurich, Division of Oncology, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. [email protected].
  2. b University Children's Hospital of Zurich, Division of Clinical Chemistry and Biochemistry, Zurich, Switzerland.
  3. c University Children's Hospital of Zurich, Division of Oncology, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland.

PMID: 30736130 DOI: 10.1586/17446651.2.5.677

Abstract

Similar to many other growth factor systems, the IGF system consists of more than a single ligand interacting with a single receptor. There are three ligands (IGF-I, IGF-II and insulin) that interact with at least four receptors. In addition, the IGF system also involves six well-characterized binding proteins that regulate IGF action. Type I IGF receptor-mediated signaling plays a fundamental role in cell growth and malignant transformation and is an important mediator of anti-apoptotic signals. This review describes the roles of IGF signaling in childhood tumors of the CNS and PNS, including neuroblastoma, medulloblastoma, atypical teratoid/rhabdoid tumors and craniopharyngioma. Moreover, it describes strategies to disrupt the IGF signaling as a potential cancer therapy.

Keywords: IGF-IR; brain tumor; cancer; child; neuroblastoma; novel therapies

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