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Shen F, Jiang L, Han F, et al. Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke. Aging Dis. 2019;10(1):12-22doi: 10.14336/AD.2018.0205.
Shen, F., Jiang, L., Han, F., Degos, V., Chen, S., & Su, H. (2019). Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke. Aging and disease, 10(1), 12-22. https://doi.org/10.14336/AD.2018.0205
Shen, Fanxia, et al. "Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke." Aging and disease vol. 10,1 (2019): 12-22. doi: https://doi.org/10.14336/AD.2018.0205
Shen F, Jiang L, Han F, Degos V, Chen S, Su H. Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke. Aging Dis. 2019 Feb 01;10(1):12-22. doi: 10.14336/AD.2018.0205. eCollection 2019 Feb. PMID: 30705764; PMCID: PMC6345332.
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Aging Dis. 2019 Feb 01;10(1):12-22. doi: 10.14336/AD.2018.0205. eCollection 2019 Feb.

Increased Inflammatory Response in Old Mice is Associated with More Severe Neuronal Injury at the Acute Stage of Ischemic Stroke.

Aging and disease

Fanxia Shen, Lidan Jiang, Frank Han, Vincent Degos, Shengdi Chen, Hua Su

Affiliations

  1. 1Department of Neurology & Institute of Neurology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
  2. 2Center for Cerebrovascular Research, Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143, USA.

PMID: 30705764 PMCID: PMC6345332 DOI: 10.14336/AD.2018.0205

Abstract

Stroke occurs mostly in patients with advanced age. Elderly patients have a less favorable prognosis compared with young adult patients. To understand the underlying mechanisms, we tested our hypothesis that an increased inflammatory response to acute ischemic injury in old stroke mice leads to more severe brain damage and behavioral dysfunction. An ischemic stroke model was created in 2- and 12-month-old C57BL/6 mice through permanent occlusion of the left distal middle cerebral artery (dMCAO). Infarct/atrophy volumes were quantified by staining the brain sections with Cresyl Violet. Sensorimotor function was assessed using the corner test and adhesive removal test. Quantification of CD68

Keywords: blood-brain barrier; cytokine; ischemic stroke; macrophage; permeability

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