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Duncan HF, Kobayashi Y, Shimizu E. Growth Factors and Cell Homing in Dental Tissue Regeneration. Curr Oral Health Rep. 2018;5(4):276-285doi: 10.1007/s40496-018-0194-y.
Duncan, H. F., Kobayashi, Y., & Shimizu, E. (2018). Growth Factors and Cell Homing in Dental Tissue Regeneration. Current oral health reports, 5(4), 276-285. https://doi.org/10.1007/s40496-018-0194-y
Duncan, Henry F, et al. "Growth Factors and Cell Homing in Dental Tissue Regeneration." Current oral health reports vol. 5,4 (2018): 276-285. doi: https://doi.org/10.1007/s40496-018-0194-y
Duncan HF, Kobayashi Y, Shimizu E. Growth Factors and Cell Homing in Dental Tissue Regeneration. Curr Oral Health Rep. 2018 Dec;5(4):276-285. doi: 10.1007/s40496-018-0194-y. Epub 2018 Sep 17. PMID: 30705803; PMCID: PMC6350522.
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Curr Oral Health Rep. 2018 Dec;5(4):276-285. doi: 10.1007/s40496-018-0194-y. Epub 2018 Sep 17.

Growth Factors and Cell Homing in Dental Tissue Regeneration.

Current oral health reports

Henry F Duncan, Yoshifumi Kobayashi, Emi Shimizu

Affiliations

  1. Division of Restorative Dentistry & Periodontology, Dublin Dental University Hospital, Trinity College Dublin, University of Dublin, Lincoln Place, Dublin, Ireland.
  2. Oral Biology Department, Rutgers School of Dental Medicine, 110 Bergen Street, Newark, NJ, USA.

PMID: 30705803 PMCID: PMC6350522 DOI: 10.1007/s40496-018-0194-y

Abstract

PURPOSE OF REVIEW: To summarize current views on the role and therapeutic potential of growth factors (GFs) within endodontic cell homing.

RECENT FINDINGS: Cell homing/revitalization techniques aim to regenerate dentin and pulp using endogenous cells. Clinically, revitalization has successfully created new vital tissue in necrotic permanent teeth with an open apex; however, there is no evidence of new odontoblasts, pulp tissue, or predictable extension in root length. Although the response is reparative rather than regenerative, exciting opportunities to improve these biologically-based strategies remain by (1) efficiently sequestering dentin-matrix-components (DMCs) using irrigants and dental materials (2) designing next-generation GF-releasing scaffold materials and (3) utilizing other sources of GF such as cells and plasma-rich plasma and plasma-rich fibrin.

SUMMARY: GFs can promote reparative-dentinogenesis and pulp-like tissue formation. The future development and clinical approval of GF-functionalized-scaffolds is a priority; however, current focus should be to harness DMCs and target the interaction of stem cells and GFs.

Keywords: Cell homing; Dental pulp stem cell; Dentin-pulp complex; Functionalized scaffolds; Growth factors; Regenerative endodontics

Conflict of interest statement

Conflict of Interest The authors declare that they have no conflict of interest.

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